{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:08:53Z","timestamp":1792156133451,"version":"4.4.0"},"reference-count":162,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Leishmaniasis, a chronic and persistent intracellular protozoal infection caused by many different species within the genus Leishmania, is an unfamiliar disease to most North American providers. Clinical presentations may include asymptomatic and symptomatic visceral leishmaniasis (so-called Kala-azar), as well as cutaneous or mucosal disease. Although cutaneous leishmaniasis (caused by Leishmania mexicana in the United States) is endemic in some southwest states, other causes for concern include reactivation of imported visceral leishmaniasis remotely in time from the initial infection, and the possible long-term complications of chronic inflammation from asymptomatic infection. Climate change, the identification of competent vectors and reservoirs, a highly mobile populace, significant population groups with proven exposure history, HIV, and widespread use of immunosuppressive medications and organ transplant all create the potential for increased frequency of leishmaniasis in the U.S. Together, these factors could contribute to leishmaniasis emerging as a health threat in the U.S., including the possibility of sustained autochthonous spread of newly introduced visceral disease. We summarize recent data examining the epidemiology and major risk factors for acquisition of cutaneous and visceral leishmaniasis, with a special focus on implications for the United States, as well as discuss key emerging issues affecting the management of visceral leishmaniasis.<\/jats:p>","DOI":"10.3390\/microorganisms9030578","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T20:17:40Z","timestamp":1615493860000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Leishmaniasis in the United States: Emerging Issues in a Region of Low Endemicity"],"prefix":"10.3390","volume":"9","author":[{"given":"John M.","family":"Curtin","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Walter Reed National Military Medical Center, Bethesda, MD 20814, USA"},{"name":"Infectious Diseases Division, Uniformed Services University, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi E.","family":"Aronson","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Uniformed Services University, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"Incident diagnoses of leishmaniasis, active and reserve components, U.S. Armed Forces, 2001\u20132016","volume":"24","author":"Stahlman","year":"2017","journal-title":"MSMR"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/cid\/ciy811","article-title":"Asymptomatic Visceral Leishmania infantum Infection in US Soldiers Deployed to Iraq","volume":"68","author":"Mody","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4269\/ajtmh.1996.55.547","article-title":"Leishmaniasis in Texas: Epidemiology and clinical aspects of human cases","volume":"55","author":"McHugh","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1067\/mjd.2002.124606","article-title":"Cutaneous leishmaniasis: Texas case diagnosed by electron microscopy","volume":"47","author":"Maloney","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jaad.2007.11.008","article-title":"Cutaneous leishmaniasis in Texas: A northern spread of endemic areas","volume":"58","author":"Wright","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4269\/ajtmh.2012.11-0717","article-title":"Case report: Emergence of autochthonous cutaneous leishmaniasis in northeastern Texas and southeastern Oklahoma","volume":"88","author":"Clarke","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/jamadermatol.2018.2133","article-title":"Incidence of Endemic Human Cutaneous Leishmaniasis in the United States","volume":"154","author":"McIlwee","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/PAS.0000000000001177","article-title":"Cutaneous Leishmaniasis: Contribution of Routine Histopathology in Unexpected Encounters","volume":"43","author":"Taxy","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.4269\/ajtmh.20-0107","article-title":"An Atypical Case of Autochthonous Cutaneous Leishmaniasis Associated with Naturally Infected Phlebotomine Sand Flies in Texas, United States","volume":"103","author":"Kipp","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/infdis\/165.3.518","article-title":"The Natural History of Cutaneous Leishmaniasis in Guatemala","volume":"165","author":"Herwaldt","year":"1992","journal-title":"J. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3201\/eid1809.120184","article-title":"Autochthonous Leishmania siamensis in horse, Florida, USA","volume":"18","author":"Reuss","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcpa.2019.09.011","article-title":"Cutaneous Leishmaniosis caused by Leishmania martiniquensis in a Horse in Florida","volume":"173","author":"Menezes","year":"2019","journal-title":"J. Comp. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/030098588001700110","article-title":"Endemic Canine Leishmaniasis","volume":"17","author":"Anderson","year":"1980","journal-title":"Veter. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3201\/eid1203.050811","article-title":"Canine Visceral Leishmaniasis, United States and Canada, 2000\u20132003","volume":"12","author":"Duprey","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2460\/javma.2003.222.603","article-title":"Seroprevalence of antibodies against Leishmania spp. among dogs in the United States","volume":"222","author":"Grosjean","year":"2003","journal-title":"J. Am. Veter. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Boggiatto, P.M., Gibson-Corley, K.N., Metz, K., Gallup, J.M., Hostetter, J.M., Mullin, K., and Petersen, C.A. (2011). Transplacental Transmission of Leishmania infantum as a Means for Continued Disease Incidence in North America. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001019"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/j.tcam.2009.06.006","article-title":"Leishmaniasis, an Emerging Disease Found in Companion Animals in the United States","volume":"24","author":"Petersen","year":"2009","journal-title":"Top. Companion Anim. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3201\/eid2112.141167","article-title":"Vectorborne Transmission of Leishmania infantum from Hounds, United States","volume":"21","author":"Schaut","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"802712","DOI":"10.1155\/2009\/802712","article-title":"New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown","volume":"2009","author":"Petersen","year":"2009","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/rvsc.2001.0527","article-title":"Canine visceral leishmaniasis: Dog infectivity to sand flies from non-endemic areas","volume":"72","author":"Travi","year":"2002","journal-title":"Res. Veter. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1093\/cid\/ciu386","article-title":"Cutaneous Leishmaniasis in North Dakota","volume":"59","author":"Douvoyiannis","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jmedent\/24.2.243","article-title":"Experimental Transmission of Leishmania mexicana by a North American Sand Fly, Lutzomyia anthophora (Diptera: Psychodidae)","volume":"24","author":"Perkins","year":"1987","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jmedent\/30.3.631","article-title":"Isolation of Leishmania mexicana (Kinetoplastida: Trypanosomatidae) from Lutzomyia anthophora (Diptera: Psychodidae) Collected in Texas","volume":"30","author":"McHugh","year":"1993","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1603\/0022-2585-38.2.268","article-title":"Population Dynamics of Sand Flies (Diptera: Psychodidae) at Two Foci of Leishmaniasis in Texas","volume":"38","author":"McHugh","year":"2001","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.7205\/MILMED-D-00-4309","article-title":"Species Diversity and Relative Abundance of Phlebotomine Sand Flies (Diptera: Psychodidae) on Three Army Installations in the Southern United States and Susceptibility of a Domestic Sand Fly to Infection With Old World Leishmania major","volume":"174","author":"Claborn","year":"2009","journal-title":"Mil. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1603\/ME12105","article-title":"First Report of Phlebotomine Sand Flies (Diptera: Psychodidae) in Kansas and Missouri, and a PCR Method to Distinguish Lutzomyia shannoni from Lutzomyia vexator","volume":"49","author":"Weng","year":"2012","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/jmedent\/24.4.458","article-title":"Experimental Transmission of Leishmania mexicana to Hamsters by Bites of Phlebotomine Sand Flies (Diptera: Psychodidae) from the United States","volume":"24","author":"Lawyer","year":"1987","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/00034983.1966.11686426","article-title":"Experimental transmission of Leishmania mexicana by Lutzomyia cruciata","volume":"60","author":"Williams","year":"1966","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4269\/ajtmh.2003.69.470","article-title":"Short Report: A Disseminated Infection of Leishmania mexicana in an eastern woodrat, Neotoma floridana, Collected in Texas","volume":"69","author":"McHugh","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2307\/3282995","article-title":"Isolation of Leishmania mexicana from Neotoma micropus Collected in Texas","volume":"76","author":"McHugh","year":"1990","journal-title":"J. Parasitol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4269\/ajtmh.1995.53.73","article-title":"Leishmaniasis in Texas: Prevalence and seasonal transmission of Leishmania mexicana in Neotoma micropus","volume":"53","author":"Kerr","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0074-02762003000200002","article-title":"Temporal and spatial distribution of Leishmania mexicana infections in a population of Neotoma micropus","volume":"98","author":"Raymond","year":"2003","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4269\/ajtmh.1999.61.378","article-title":"Short report: A focus of Leishmania mexicana near Tucson, Arizona","volume":"61","author":"Kerr","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jaad.2009.08.034","article-title":"Cutaneous leishmaniasis in Texas","volume":"62","author":"McHugh","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1051\/parasite\/2017034","article-title":"Ecology of phlebotomine sandflies and putative reservoir hosts of leishmaniasis in a border area in Northeastern Mexico: Implications for the risk of transmission of Leishmania mexicana in Mexico and the USA","volume":"24","author":"Becker","year":"2017","journal-title":"Parasite"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1638\/2013-0151R.1","article-title":"Survey of antibodies Toleishmania spp. in wild canids from Pennsylvania and Tennessee","volume":"44","author":"Rosypal","year":"2013","journal-title":"J. Zoo Wildl. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Intergovernmental Panel on Climate Change (IPCC) (2021, February 25). Summary for Policymakers of IPCC Special Report on Global Warming of 1.5 \u00b0C Approved by Governments. Available online: https:\/\/www.ipcc.ch\/2018\/10\/08\/summary-for-policymakers-of-ipcc-special-report-on-global-warming-of-1-5c-approved-by-governments\/.","DOI":"10.1017\/9781009157940.001"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Koch, L.K., Kochmann, J., Klimpel, S., and Cunze, S. (2017). Modeling the climatic suitability of leishmaniasis vector species in Europe. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-13822-1"},{"key":"ref_39","first-page":"955","article-title":"The effect of temperature on Leishmania (Kinetoplastida: Trypanosomatidae) development in sand flies","volume":"50","author":"Hlavacova","year":"2013","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1051\/parasite\/1983586633","article-title":"Leishmania major (Yakimoff et Shokkor 1914), the agent of Gafsa boil","volume":"58","author":"Rioux","year":"1983","journal-title":"Ann. Parasitol. Hum. Comp."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1051\/parasite\/1987624354","article-title":"The laboratory colonization of Phlebotomus ariasi (Diptera: Psychodidae)","volume":"62","year":"1987","journal-title":"Ann. Parasitol. Hum. Comp."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0035-9203(86)90213-0","article-title":"Preliminary field observations on the flight speed of a phlebotomine sandfly","volume":"80","author":"Wilkes","year":"1986","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, C., Wang, O., Strutz, S.E., Gonz\u00e1lez-Salazar, C., S\u00e1nchez-Cordero, V., and Sarkar, S. (2010). Climate Change and Risk of Leishmaniasis in North America: Predictions from Ecological Niche Models of Vector and Reservoir Species. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000585"},{"key":"ref_44","first-page":"1178633617732296","article-title":"Climate Change Contribution to the Emergence or Re-Emergence of Parasitic Diseases","volume":"10","author":"Short","year":"2017","journal-title":"Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Moo-Llanes, D., Ibarra-Cerde\u00f1a, C.N., Rebollar-Tellez, E.A., Ib\u00e1\u00f1ez-Bernal, S., Gonzalez, C., and Ramsey, J.M. (2013). Current and Future Niche of North and Central American Sand Flies (Diptera: Psychodidae) in Climate Change Scenarios. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002421"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jaad.2006.06.044","article-title":"Liposomal amphotericin B in comparison to sodium stibogluconate for cutaneous infection due to Leishmania braziliensis","volume":"56","author":"Solomon","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.4269\/ajtmh.2010.10-0171","article-title":"Lipsosomal Amphotericin B for Treatment of Cutaneous Leishmaniasis","volume":"83","author":"Wortmann","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"779","DOI":"10.7326\/0003-4819-118-10-199305150-00004","article-title":"American Cutaneous Leishmaniasis in U.S. Travelers","volume":"118","author":"Herwaldt","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Boggild, A.K., Caumes, E., Grobusch, M.P., Schwartz, E., Hynes, N.A., Libman, M., Connor, B.A., Chakrabarti, S., Parola, P., and Keystone, J.S. (2019). Cutaneous and mucocutaneous leishmaniasis in travellers and migrants: A 20-year GeoSentinel Surveillance Network analysis. J. Travel Med., 26.","DOI":"10.1093\/jtm\/taz055"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.4269\/ajtmh.19-0861","article-title":"Case Report: Mucosal Leishmaniasis in New York City","volume":"102","author":"Murray","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00005792-194709000-00001","article-title":"Kala azar in American military personnel, report of 30 cases","volume":"26","author":"Most","year":"1947","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJM199305133281904","article-title":"Visceral Infection Caused by Leishmania tropica in Veterans of Operation Desert Storm","volume":"328","author":"Magill","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1001\/archinte.167.17.1899","article-title":"Visceral Leishmaniasis: Clinical Observations in 4 US Army Soldiers Deployed to Afghanistan or Iraq, 2002\u20132004","volume":"167","author":"Myles","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Scheufele, C.J., Giesey, R.L., and Delost, G.R. (2020). The global, regional, and national burden of leishmaniasis: An ecologic analysis from the Global Burden of Disease Study 1990\u20132017. J. Am. Acad. Dermatol.","DOI":"10.1016\/j.jaad.2020.08.043"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100540","DOI":"10.1016\/j.nmni.2019.100540","article-title":"Leishmania (Mundinia) spp.: From description to emergence as new human and animal Leishmania pathogens","volume":"30","author":"Sereno","year":"2019","journal-title":"New Microbes New Infect."},{"key":"ref_56","first-page":"73","article-title":"Leishmania spp. and leishmaniasis on the Caribbean islands","volume":"114","author":"Yao","year":"2020","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.3201\/eid2511.181548","article-title":"Non-Leishmania Parasite in Fatal Visceral Leishmaniasis\u2013Like Disease, Brazil","volume":"25","author":"Maruyama","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41564-018-0349-6","article-title":"Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease","volume":"4","author":"Blauwkamp","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1128\/JCM.00845-17","article-title":"Identification of Leishmania by Matrix-Assisted Laser Desorption Ionization\u2013Time of Flight (MALDI-TOF) Mass Spectrometry Using a Free Web-Based Application and a Dedicated Mass-Spectral Library","volume":"55","author":"Lachaud","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jdcr.2020.03.014","article-title":"Leishmania tropica infection of the ear treated with photodynamic therapy","volume":"6","author":"Goldin","year":"2020","journal-title":"JAAD Case Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1017\/S0031182018000124","article-title":"The successful use of radiofrequency-induced heat therapy for cutaneous leishmaniasis: A review","volume":"145","author":"David","year":"2018","journal-title":"Parasitology"},{"key":"ref_62","unstructured":"Drugs for Neglected Tropical Disease Initiative (2021, February 25). Cutaneous Leishmaniasis. Available online: https:\/\/dndi.org\/diseases\/cutaneous-leishmaniasis\/."},{"key":"ref_63","unstructured":"Drugs for Neglected Tropical Disease Initiative (2021, February 25). Visceral Leishmaniasis. Available online: https:\/\/dndi.org\/diseases\/visceral-leishmaniasis\/."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.celrep.2019.08.004","article-title":"Beta-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: A Crucial Role for IL-32","volume":"28","author":"Silva","year":"2019","journal-title":"Cell Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2478\/helm-2018-0021","article-title":"Beta-Glucan and Parasites","volume":"55","author":"Vetvicka","year":"2018","journal-title":"Helminthologia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/j.1469-0691.2011.03640.x","article-title":"Clinical pleiomorphism in human leishmaniases, with special mention of asymptomatic infection","volume":"17","author":"Bastien","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4269\/ajtmh.2007.76.909","article-title":"The Epidemiology of Visceral Leishmaniasis and Asymptomatic Leishmanial Infection in a Highly Endemic Bangladeshi Village","volume":"76","author":"Bern","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1086\/313697","article-title":"Natural History of Leishmania (Leishmania) chagasi infection in Northeastern Brazil: Long-Term Follow-Up","volume":"30","author":"Jeronimo","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4269\/ajtmh.2012.10-0492","article-title":"Leishmania infantum chagasi in Northeastern Brazil: Asymptomatic Infection at the Urban Perimeter","volume":"86","author":"Lima","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1128\/JCM.42.11.5249-5255.2004","article-title":"Quantification of Leishmania infantum DNA by a Real-Time PCR Assay with High Sensitivity","volume":"42","author":"Mary","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0035-9203(01)90223-8","article-title":"The increase in risk factors for leishmaniasis worldwide","volume":"95","author":"Desjeux","year":"2001","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Hirve, S., Boelaert, M., Matlashewski, G., Mondal, D., Arana, B., Kroeger, A., and Olliaro, P. (2016). Transmission Dynamics of Visceral Leishmaniasis in the Indian Subcontinent\u2014A Systematic Literature Review. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004896"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/S2666-5247(20)30166-X","article-title":"Xenodiagnosis to evaluate the infectiousness of humans to sandflies in an area endemic for visceral leishmaniasis in Bihar, India: A transmission-dynamics study","volume":"2","author":"Singh","year":"2021","journal-title":"Lancet Microbe"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.actatropica.2011.05.012","article-title":"Importance of worldwide asymptomatic carriers of Leishmania infantum (L. chagasi) in human","volume":"119","author":"Michel","year":"2011","journal-title":"Acta Trop."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1179\/136485908X337526","article-title":"Asymptomatic human carriers of Leishmania infantum: Possible reservoirs for Mediterranean visceral leishmaniasis in southern Iran","volume":"102","author":"Fakhar","year":"2008","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4269\/ajtmh.2008.79.435","article-title":"Isolation of Leishmania tropica from a Patient with Visceral Leishmaniasis and Disseminated Cutaneous Leishmaniasis, Southern Iran","volume":"79","author":"Alborzi","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_77","unstructured":"World Health Organization (2021, February 25). WHO Fact Sheet: Leishmaniasis. 2 March 2020. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/leishmaniasis."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Bhattacharyya, T., Boelaert, M., and Miles, M.A. (2013). Comparison of Visceral Leishmaniasis Diagnostic Antigens in African and Asian Leishmania donovani Reveals Extensive Diversity and Region-specific Polymorphisms. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002057"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1128\/CMR.00080-14","article-title":"Visceral Leishmaniasis in China: An Endemic Disease under Control","volume":"28","author":"Lun","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1073\/pnas.0703678104","article-title":"Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy","volume":"104","author":"Lukes","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","unstructured":"Pan American Health Organization (2020). Annual Report of the Director of the Pan American Sanitary Bureau 2020. Saving Lives and Improving Health and Well-Being, PAHO."},{"key":"ref_82","unstructured":"World Health Organization (2020). WHO Weekly Epidemiological Record, WHO."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/B978-0-12-407679-2.00005-3","article-title":"Mechanisms of Immune Evasion in Leishmaniasis","volume":"82","author":"Gupta","year":"2013","journal-title":"Adv. Appl. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"161","DOI":"10.14411\/fp.2006.022","article-title":"Sand fly saliva: Effects on host immune response and Leishmania transmission","volume":"53","author":"Volf","year":"2006","journal-title":"Folia Parasitol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13071-016-1412-x","article-title":"Regulation of immunity during visceral Leishmania infection","volume":"9","author":"Rodrigues","year":"2016","journal-title":"Parasites Vectors"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.0105-2896.2004.00188.x","article-title":"The immunopathology of experimental visceral leishmaniasis","volume":"201","author":"Kaye","year":"2004","journal-title":"Immunol. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Rodrigues, V., LaForge, M., Campillo-Gimenez, L., Soundaramourty, C., Correia-De-Oliveira, A., Dinis-Oliveira, R.J., Ouaissi, A., Cordeiro-Da-Silva, A., Silvestre, R., and Estaquier, J. (2014). Abortive T Follicular Helper Development Is Associated with a Defective Humoral Response in Leishmania infantum-Infected Macaques. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004096"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-695X.2007.00311.x","article-title":"Immune response to leishmania: Paradox rather than paradigm","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1128\/IAI.70.11.6284-6293.2002","article-title":"Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy","volume":"70","author":"Murray","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Chakravarty, J., Hasker, E., Kansal, S., Singh, O.P., Malaviya, P., Singh, A.K., Chourasia, A., Singh, T., Sudarshan, M., and Singh, A.P. (2019). Determinants for progression from asymptomatic infection to symptomatic visceral leishmaniasis: A cohort study. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007216"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Das, V.N.R., Bimal, S., Siddiqui, N.A., Kumar, A., Pandey, K., Sinha, S.K., Topno, R.K., Mahentesh, V., Singh, A.K., and Lal, C.S. (2020). Conversion of asymptomatic infection to symptomatic visceral leishmaniasis: A study of possible immunological markers. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008272"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4269\/ajtmh.1995.53.360","article-title":"Short Report: Extended Follow-up of the Natural History of Persons Infected with Leishmania chagasi","volume":"53","author":"Evans","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Hasker, E., Malaviya, P., Gidwani, K., Picado, A., Ostyn, B., Kansal, S., Singh, R.P., Singh, O.P., Chourasia, A., and Singh, A.K. (2014). Strong Association between Serological Status and Probability of Progression to Clinical Visceral Leishmaniasis in Prospective Cohort Studies in India and Nepal. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002657"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1186\/s13071-015-1136-3","article-title":"Quantification of the natural history of visceral leishmaniasis and consequences for control","volume":"8","author":"Chapman","year":"2015","journal-title":"Parasites Vectors"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"20546","DOI":"10.2807\/1560-7917.ES2013.18.30.20546","article-title":"Re-emergence of leishmaniasis in Spain: Community outbreak in Madrid, Spain, 2009 to 2012","volume":"18","author":"Arce","year":"2013","journal-title":"Eurosurveillance"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s13071-019-3628-z","article-title":"Clinical aspects of visceral leishmaniasis caused by L. infantum in adults. Ten years of experience of the largest outbreak in Europe: What have we learned?","volume":"12","author":"Horrillo","year":"2019","journal-title":"Parasites Vectors"},{"key":"ref_97","first-page":"1800379","article-title":"Prevalence of asymptomatic Leishmania infection and associated risk factors, after an outbreak in the south-western Madrid region, Spain, 2015","volume":"24","author":"Carrillo","year":"2019","journal-title":"Eurosurveillance"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S1286-4579(02)00026-6","article-title":"Epidemiology of visceral leishmaniasis in Atbara River area, eastern Sudan: The outbreak of Barbar El Fugara village (1996\u20131997)","volume":"4","author":"Bucheton","year":"2002","journal-title":"Microbes Infect."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Babuadze, G., Alvar, J., Argaw, D., De Koning, H.P., Iosava, M., Kekelidze, M., Tsertsvadze, N., Tsereteli, D., Chakhunashvili, G., and Mamatsashvili, T. (2014). Epidemiology of Visceral Leishmaniasis in Georgia. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002725"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1093\/cid\/ciw670","article-title":"Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH)","volume":"63","author":"Aronson","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1590\/S0036-46651996000300003","article-title":"Cross-reactivity of antibodies in human infections by the kinetoplastid protozoa Trypanosoma cruzi, Leishmania chagasi and Leishmania (Viannia) braziliensis","volume":"38","author":"Vexenat","year":"1996","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1590\/0037-8682-1723-2013","article-title":"Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs","volume":"47","author":"Zanette","year":"2014","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/1469-0691.12556","article-title":"Leishmaniasis in immunosuppressed individuals","volume":"20","author":"Carrillo","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e12867","DOI":"10.1111\/ctr.12867","article-title":"Leishmaniasis in solid organ and hematopoietic stem cell transplant recipients","volume":"31","author":"Gajurel","year":"2017","journal-title":"Clin. Transplant."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.4269\/ajtmh.16-0940","article-title":"Is Visceral Leishmaniasis Different in Immunocompromised Patients without Human Immunodeficiency Virus? A Comparative, Multicenter Retrospective Cohort Analysis","volume":"97","author":"Ramos","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"967","DOI":"10.4269\/ajtmh.14-0798","article-title":"Rapid Tests and the Diagnosis of Visceral Leishmaniasis and Human Immunodeficiency Virus\/Acquired Immunodeficiency Syndrome Coinfection","volume":"93","author":"Medeiros","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/cid\/cis716","article-title":"A Global Comparative Evaluation of Commercial Immunochromatographic Rapid Diagnostic Tests for Visceral Leishmaniasis","volume":"55","author":"Cunningham","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Moreno, E.C., Gon\u00e7alves, A.V., Chaves, A.V., Melo, M.N., Lambertucci, J.R., Andrade, A.S.R., Negr\u00e3o-Corr\u00eaa, D., Antunes, C.M.D.F., and Carneiro, M. (2009). Inaccuracy of Enzyme-Linked Immunosorbent Assay Using Soluble and Recombinant Antigens to Detect Asymptomatic Infection by Leishmania infantum. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000536"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1128\/JCM.00372-14","article-title":"Molecular Tools for Diagnosis of Visceral Leishmaniasis: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy","volume":"52","author":"Leeflang","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1128\/JCM.01465-15","article-title":"A Correlative Study of Splenic Parasite Score and Peripheral Blood Parasite Load Estimation by Quantitative PCR in Visceral Leishmaniasis","volume":"53","author":"Sudarshan","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/QCO.0b013e32835c2198","article-title":"Clinical aspects of visceral leishmaniasis in HIV infection","volume":"26","author":"Jarvis","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/CMR.00061-07","article-title":"The Relationship between Leishmaniasis and AIDS: The Second 10 Years","volume":"21","author":"Alvar","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12026-013-8389-8","article-title":"The immunology of Leishmania\/HIV co-infection","volume":"56","author":"Okwor","year":"2013","journal-title":"Immunol. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/1120009X.2017.1323150","article-title":"Visceral leishmaniosis in immunocompromised host: An update and literature review","volume":"29","author":"Pagliano","year":"2017","journal-title":"J. Chemother."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1590\/0037-8682-0193-2017","article-title":"Visceral leishmaniasis and leishmaniasis-HIV coinfection: Comparative study","volume":"50","author":"Coutinho","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/CMR.10.2.298","article-title":"Leishmania and human immunodeficiency virus coinfection: The first 10 years","volume":"10","author":"Alvar","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1473-3099(08)70043-4","article-title":"Leishmaniasis among organ transplant recipients","volume":"8","author":"Antinori","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Akuffo, H., Costa, C., Van Griensven, J., Burza, S., Moreno, J., and Herrero, M. (2018). New insights into leishmaniasis in the immunosuppressed. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006375"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e13546","DOI":"10.1111\/ctr.13546","article-title":"Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients\u2014Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Morris","year":"2019","journal-title":"Clin. Transpl."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jiac.2018.05.008","article-title":"Visceral leishmaniasis in hematopoietic cell transplantation: Case report and review of the literature","volume":"24","author":"Tatarelli","year":"2018","journal-title":"J. Infect. Chemother."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1157\/13059832","article-title":"Visceral leishmaniasis related to infliximab administration","volume":"22","author":"Estany","year":"2004","journal-title":"Enferm. Infecc. Microbiol. Cl\u00edn."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/rheumatology\/kel235","article-title":"Visceral leishmaniasis infection in a rheumatoid arthritis patient treated with adalimumab","volume":"45","author":"Bassetti","year":"2006","journal-title":"Rheumatology"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Khan, A., Coakley, G., Cosgrove, C., and Lockwood, D. (2010). Let off the leash: Kala-azar following the use of tumour necrosis factor antibodies. BMJ Case Rep., 2010.","DOI":"10.1136\/bcr.04.2010.2878"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1007\/s00296-012-2483-4","article-title":"Imported case of visceral leishmaniasis presenting as pancytopenia in a Norwegian patient treated with methotrexate and etanercept for psoriasis arthritis","volume":"33","author":"Besada","year":"2013","journal-title":"Rheumatol. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.semarthrit.2013.01.006","article-title":"Leishmaniasis during anti-tumor necrosis factor therapy: Report of 4 cases and review of the literature (additional 28 cases)","volume":"43","author":"Fernandes","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s15010-018-1189-2","article-title":"Subclinical Leishmania infection in patients with rheumatic diseases under biological drugs","volume":"46","author":"Maritati","year":"2018","journal-title":"Infection"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e03940","DOI":"10.1016\/j.heliyon.2020.e03940","article-title":"Leishmania infantum asymptomatic infection in inflammatory bowel disease patients under anti-TNF therapy","volume":"6","author":"Alcover","year":"2020","journal-title":"Heliyon"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1469-0691.2011.03674.x","article-title":"Tumor necrosis factor alpha antagonist drugs and leishmaniasis in Europe","volume":"18","author":"Zanger","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Bosch-Nicolau, P., Ubals, M., Salvador, F., S\u00e1nchez-Montalv\u00e1, A., Aparicio, G., Erra, A., De Salazar, P.M., Sulleiro, E., and Molina, I. (2019). Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007708"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.1103298","article-title":"Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability","volume":"188","author":"Flynn","year":"2012","journal-title":"J. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/TP.0000000000002018","article-title":"Visceral and Cutaneous Leishmaniasis Recommendations for Solid Organ Transplant Recipients and Donors","volume":"102","author":"Clemente","year":"2018","journal-title":"Transplantation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e13548","DOI":"10.1111\/ctr.13548","article-title":"Screening of donor and candidate prior to solid organ transplantation\u2014Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Malinis","year":"2019","journal-title":"Clin. Transpl."},{"key":"ref_133","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents (2019). Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV, Department of Health and Human Services."},{"key":"ref_134","first-page":"1","article-title":"2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis","volume":"68","author":"Singh","year":"2016","journal-title":"Arthritis Rheum."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ajg.2018.27","article-title":"ACG Clinical Guideline: Management of Crohn\u2019s Disease in Adults","volume":"113","author":"Lichtenstein","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/00365540410019426","article-title":"Two Case Reports of Symptomatic Visceral Leishmaniasis in AIDS Patients Concomitant with Immune Reconstitution due to Antiretroviral Therapy","volume":"36","author":"Berry","year":"2004","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0002-9343(97)89503-4","article-title":"Prophylaxis of visceral leishmaniasis in human immunodeficiency virus-infected patients","volume":"100","author":"Ribera","year":"1996","journal-title":"Am. J. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1097\/00002030-200012220-00020","article-title":"Discontinuation of secondary anti-Leishmania prophylaxis in HIV-infected patients who have responded to highly active antiretroviral therapy","volume":"14","author":"Berenguer","year":"2000","journal-title":"AIDS"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cmi.2014.09.002","article-title":"Risk factors, clinical features and outcomes of visceral leishmaniasis in solid-organ transplant recipients: A retrospective multicenter case\u2013control study","volume":"21","author":"Clemente","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_140","unstructured":"Centers for Disease Control and Prevention (2021, February 21). Leishmaniasis: Resources for Health Professionals, Available online: https:\/\/www.cdc.gov\/parasites\/leishmaniasis\/health_professionals\/index.html."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0255-0857(21)02344-6","article-title":"Transfusion transmitted leishmaniasis: A case report and review of literature","volume":"24","author":"Dey","year":"2006","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_142","first-page":"325","article-title":"The first two cases of transfusion kala-azar","volume":"66","author":"Chung","year":"1948","journal-title":"Chin. Med. J."},{"key":"ref_143","first-page":"S45","article-title":"Transfusion-transmitted leishmaniasis: A practical review","volume":"56","author":"Fisa","year":"2016","journal-title":"Transfusion"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4269\/ajtmh.1997.57.168","article-title":"Prevalence of Anti-Leishmania donovani Antibody Among Brazilian Blood Donors and Multiply Transfused Hemodialysis Patients","volume":"57","author":"Luz","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Fukutani, K.F., Figueiredo, V., Celes, F.S., Cristal, J.R., Barral, A., Barral-Netto, M., and de Oliveira, C.I. (2014). Serological survey of Leishmania infection in blood donors in Salvador, Northeastern Brazil. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-422"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Fran\u00e7a, A.D.O., Pompilio, M.A., Pontes, E.R.J.C., De Oliveira, M.P., Pereira, L., Lima, R.B., Goto, H., Sanchez, M.C.A., Fujimori, M., and Lima-J\u00fanior, M.S.D.C. (2018). Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198199"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/j.1537-2995.2008.01708.x","article-title":"Asymptomatic infection by Leishmania infantum in blood donors from the Balearic Islands (Spain)","volume":"48","author":"Riera","year":"2008","journal-title":"Transfusion"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Dhaliwal, A., Chauhan, A., Aggarwal, D., Davda, P., David, M., Amel-Kashipaz, R., Brown, R., Dedicoat, M., Clark, F., and Shah, T. (2021). Donor acquired visceral leishmaniasis following liver transplantation. Front. Gastroenterol.","DOI":"10.1136\/flgastro-2020-101659"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Fabiani, S., Fortunato, S., and Bruschi, F. (2018). Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades. Pathogens, 7.","DOI":"10.3390\/pathogens7030065"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Molina, R., Jim\u00e9nez, M., Garc\u00eda-Mart\u00ednez, J., Mart\u00edn, J.V.S., Carrillo, E., S\u00e1nchez, C., Moreno, J., Alves, F., and Alvar, J. (2020). Role of asymptomatic and symptomatic humans as reservoirs of visceral leishmaniasis in a Mediterranean context. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008253"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4269\/ajtmh.1999.60.51","article-title":"Infection of sand flies by humans coinfected with Leishmania infantum and human immunodeficiency virus","volume":"60","author":"Molina","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.16-0883","article-title":"Human Competence to Transmit Leishmania infantum to Lutzomyia longipalpis and the Influence of Human Immunodeficiency Virus Infection","volume":"98","author":"Ferreira","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_153","unstructured":"Pahwa, R., Goyal, A., Bansal, P., and Jialal, I. (2020). Chronic Inflammation, StatPearls."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/gerona\/glz130","article-title":"Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults","volume":"74","author":"Piber","year":"2019","journal-title":"J. Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Faleiro, R.J., Kumar, R., Hafner, L.M., and Engwerda, C.R. (2014). Immune Regulation during Chronic Visceral Leishmaniasis. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002914"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","article-title":"Systemic Effects of Inflammation on Health during Chronic HIV Infection","volume":"39","author":"Deeks","year":"2013","journal-title":"Immunity"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamainternmed.2013.3728","article-title":"HIV Infection and the Risk of Acute Myocardial Infarction","volume":"173","author":"Freiberg","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/gerona\/62.11.1279","article-title":"HIV-1 Infection Is Associated with an Earlier Occurrence of a Phenotype Related to Frailty","volume":"62","author":"Desquilbet","year":"2007","journal-title":"J. Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bjid.2012.11.007","article-title":"Aging with HIV: A practical review","volume":"17","author":"Cardoso","year":"2013","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_160","first-page":"133","article-title":"Management of Long-Term Complications of HIV Disease: Focus on Cardiovascular Disease","volume":"25","author":"Currier","year":"2018","journal-title":"Top. Antivir. Med."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Navas, A., Fern\u00e1ndez, O., Gallego-Mar\u00edn, C., Castro, M.D.M., Rosales-Chilama, M., Murillo, J., Cossio, A., McMahon-Pratt, D., Saravia, N.G., and G\u00f3mez, M.A. (2020). Profiles of Local and Systemic Inflammation in the Outcome of Treatment of Human Cutaneous Leishmaniasis Caused by Leishmania (Viannia). Infect. Immun., 88.","DOI":"10.1128\/IAI.00764-19"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3389\/fimmu.2018.03001","article-title":"Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis","volume":"9","author":"Covre","year":"2019","journal-title":"Front. 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