{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:33:17Z","timestamp":1789439597590,"version":"build-2803163510"},"reference-count":177,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.<\/jats:p>","DOI":"10.3390\/microorganisms9030634","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T11:41:06Z","timestamp":1616067666000},"page":"634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-7206","authenticated-orcid":false,"given":"Muriel","family":"Billamboz","sequence":"first","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur Lille, Universit\u00e9 Lille, U1167\u2014RID-AGE\u2014Facteurs de Risque et D\u00e9terminants Mol\u00e9culaires des Maladies li\u00e9es au Vieillissement, F-59000 Lille, France"},{"name":"Junia, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Fatima","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurugram 122413, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Hameed","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurugram 122413, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-975X","authenticated-orcid":false,"given":"Samir","family":"Jawhara","sequence":"additional","affiliation":[{"name":"UMR 8576-UGSF-Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Centre National de la Recherche Scientifique, INSERM U1285, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","article-title":"Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital","volume":"53","author":"Satoh","year":"2009","journal-title":"Microbiol. 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