{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:09:57Z","timestamp":1790759397867,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zoonoses Sequencing Network BMBF-ZooSeq","award":["01KI2010A, 01KI2010C, 01KI1905A"],"award-info":[{"award-number":["01KI2010A, 01KI2010C, 01KI1905A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>In May 2017, a hospitalized index case of tick-borne encephalitis (TBE) was confirmed by Serology. The case was linked to alimentary infection by raw milk from a goat farm in the region of T\u00fcbingen, Baden-W\u00fcrttemberg, Germany, where no previous TBE cases in the area had been reported before. The TBE focus was confirmed by isolation of the TBE virus from ticks and Serological confirmation of past infection in one of the five flock goats. Additional investigations by the local public health office identified 27 consumers of goat milk at the putative period of exposure. For 20\/27 exposed persons, anamnestic information was gained by the local public health office. Twelve\/fourteen exposed and non-vaccinated people developed clinical illness and were confirmed as TBE cases by Serology. Five\/six vaccinated and exposed people did not develop the disease. The one exposed and vaccinated person had their last TBE vaccination booster more than 15 years ago, and therefore a booster was more than 10 years overdue. None of the regularly vaccinated and exposed persons developed clinical overt TBE infection. We report the first known TBE outbreak, during which, protection by TBE vaccination against alimentary TBE infection was demonstrated.<\/jats:p>","DOI":"10.3390\/microorganisms9050889","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:25:10Z","timestamp":1619040310000},"page":"889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Tick-Borne Encephalitis Vaccination Protects from Alimentary TBE Infection: Results from an Alimentary Outbreak"],"prefix":"10.3390","volume":"9","author":[{"given":"Lidia","family":"Chitimia-Dobler","sequence":"first","affiliation":[{"name":"Bundeswehr Institute of Microbiology, 80937 Munich, Germany"},{"name":"Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lindau","sequence":"additional","affiliation":[{"name":"Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Oehme","sequence":"additional","affiliation":[{"name":"State Health Office Baden-W\u00fcrttemberg, 70191 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malena","family":"Bestehorn-Willmann","sequence":"additional","affiliation":[{"name":"Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Antwerpen","sequence":"additional","affiliation":[{"name":"Bundeswehr Institute of Microbiology, 80937 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Drehmann","sequence":"additional","affiliation":[{"name":"Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hierl","sequence":"additional","affiliation":[{"name":"District Health Office Zollernalbkreis, 72379 Hechingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Mackenstedt","sequence":"additional","affiliation":[{"name":"Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Dobler","sequence":"additional","affiliation":[{"name":"Bundeswehr Institute of Microbiology, 80937 Munich, Germany"},{"name":"Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ttbdis.2010.10.007","article-title":"Tick-borne encephalitis 2010: Epidemiology, risk areas, and virus strains in Europe and Asia-an Overview","volume":"2","author":"Suss","year":"2011","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.antiviral.2019.01.014","article-title":"Tick-borne encephalitis in europe and russia: Review of pathogenesis, clinical features, therapy, and vaccines","volume":"164","author":"Ruzek","year":"2019","journal-title":"Antiviral. 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