{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:38:16Z","timestamp":1767890296565,"version":"3.49.0"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa Inova Fiocruz","award":["1131778468"],"award-info":[{"award-number":["1131778468"]}]},{"name":"CNPq","award":["435536\/2018-4"],"award-info":[{"award-number":["435536\/2018-4"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI136032"],"award-info":[{"award-number":["AI136032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Leishmania, an intracellular parasite species, causes lesions on the skin and in the mucosa and internal organs. The dissemination of infected host cells containing Leishmania is crucial to parasite survival and the establishment of infection. Migratory phenomena and the mechanisms underlying the dissemination of Leishmania-infected human dendritic cells (hDCs) remain poorly understood. The present study aimed to investigate differences among factors involved in hDC migration by comparing infection with visceral leishmaniasis (VL) induced by Leishmaniainfantum with diverse clinical forms of tegumentary leishmaniasis (TL) induced by Leishmaniabraziliensis or Leishmania amazonensis. Following the infection of hDCs by isolates obtained from patients with different clinical forms of Leishmania, the formation of adhesion complexes, actin polymerization, and CCR7 expression were evaluated. We observed increased hDC migration following infection with isolates of L. infantum (VL), as well as disseminated (DL) and diffuse (DCL) forms of cutaneous leishmaniasis (CL) caused by L. braziliensis and L. amazonensis, respectively. Increased expression of proteins involved in adhesion complex formation and actin polymerization, as well as higher CCR7 expression, were seen in hDCs infected with L. infantum, DL and DCL isolates. Together, our results suggest that hDCs play an important role in the dissemination of Leishmania parasites in the vertebrate host.<\/jats:p>","DOI":"10.3390\/microorganisms9061268","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T02:55:28Z","timestamp":1623380128000},"page":"1268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination"],"prefix":"10.3390","volume":"9","author":[{"given":"Amanda","family":"Rebou\u00e7as","sequence":"first","affiliation":[{"name":"Laboratory of Host\u2014Parasite Interaction and Epidemiology, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00edlla S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Host\u2014Parasite Interaction and Epidemiology, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian S.","family":"Medina","sequence":"additional","affiliation":[{"name":"Immunology Service, Professor Edgard Santos Hospital, Federal University of Bahia, Salvador 40170-110, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno D.","family":"Paredes","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Cell Therapy, S\u00e3o Rafael Hospital, Salvador 41253-900, BA, Brazil"},{"name":"D\u2019Or Institute for Research and Education, Salvador 41253-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana S.","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Cell Therapy, S\u00e3o Rafael Hospital, Salvador 41253-900, BA, Brazil"},{"name":"D\u2019Or Institute for Research and Education, Salvador 41253-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno S. F.","family":"Souza","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Cell Therapy, S\u00e3o Rafael Hospital, Salvador 41253-900, BA, Brazil"},{"name":"D\u2019Or Institute for Research and Education, Salvador 41253-900, BA, Brazil"},{"name":"Laboratory of Tissue Engineering and Immunopharmacology, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria M.","family":"Borges","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Biomarkers, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-6789","authenticated-orcid":false,"given":"Albert","family":"Schriefer","sequence":"additional","affiliation":[{"name":"Immunology Service, Professor Edgard Santos Hospital, Federal University of Bahia, Salvador 40170-110, BA, Brazil"},{"name":"Department of Bio-Interaction, Institute of Health Sciences, Federal University of Bahia, Salvador 40110-902, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S. T.","family":"Veras","sequence":"additional","affiliation":[{"name":"Laboratory of Host\u2014Parasite Interaction and Epidemiology, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia I.","family":"Brodskyn","sequence":"additional","affiliation":[{"name":"Laboratory of Host\u2014Parasite Interaction and Epidemiology, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-8839","authenticated-orcid":false,"given":"Juliana P. B.","family":"de Menezes","sequence":"additional","affiliation":[{"name":"Laboratory of Host\u2014Parasite Interaction and Epidemiology, Gon\u00e7alo Moniz Institute, Salvador 40296-710, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"ref_1","unstructured":"WHO (2010). 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