{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:57:44Z","timestamp":1773950264738,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013699","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["IP7 \/ 01KI2007D; zoonoses research consortium PAC-Campylobacter"],"award-info":[{"award-number":["IP7 \/ 01KI2007D; zoonoses research consortium PAC-Campylobacter"]}],"id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006360","name":"Bundesministerium f\u00fcr Wirtschaft und Energie","doi-asserted-by":"publisher","award":["ZIM, ZF4117908 AJ8"],"award-info":[{"award-number":["ZIM, ZF4117908 AJ8"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Foodborne Campylobacter jejuni infections are on the rise and responsible for worldwide serious health issues. Increasing resistance of C. jejuni strains against antimicrobial treatments, necessitates antibiotics-independent treatment options for acute campylobacteriosis. Activated charcoal (AC) constitutes a long-known and safe compound for the treatment of bacterial enteritis. In this preclinical intervention study, we addressed potential anti-pathogenic and immune-modulatory effects of AC during acute experimental campylobacteriosis. Therefore, microbiota-depleted IL-10\u2212\/\u2212 mice were infected with C. jejuni by gavage and challenged with either AC or placebo via the drinking water starting on day 2 post-infection. On day 6 post-infection, AC as compared to placebo-treated mice did not only harbor lower intestinal pathogen loads but also presented with alleviated C. jejuni-induced clinical signs such as diarrhea and wasting symptoms. The improved clinical outcome of AC-treated mice was accompanied by less colonic epithelial cell apoptosis and reduced pro-inflammatory immune responses in the intestinal tract. Notably, AC treatment did not only alleviate intestinal, but also extra-intestinal and systemic immune responses as indicated by dampened pro-inflammatory mediator secretion. Given the anti-pathogenic and immune-modulatory properties of AC in this study, a short-term application of this non-toxic drug constitutes a promising antibiotics-independent option for the treatment of human campylobacteriosis.<\/jats:p>","DOI":"10.3390\/microorganisms9071424","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T02:44:39Z","timestamp":1625107479000},"page":"1424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Disease-Alleviating Effects of Peroral Activated Charcoal Treatment in Acute Murine Campylobacteriosis"],"prefix":"10.3390","volume":"9","author":[{"given":"Stefan","family":"Bereswill","sequence":"first","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Weschka","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":false,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e02814","DOI":"10.1016\/j.heliyon.2019.e02814","article-title":"Human campylobacteriosis: A public health concern of global importance","volume":"5","author":"Igwaran","year":"2019","journal-title":"Heliyon"},{"key":"ref_2","unstructured":"WHO (World Health Organisation) (2020, June 04). Campylobacter, Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/campylobacter."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1128\/CMR.00006-15","article-title":"Global Epidemiology of Campylobacter Infection","volume":"28","author":"Kaakoush","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_4","first-page":"1","article-title":"Human Campylobacteriosis-A Serious Infectious Threat in a One Health Perspective","volume":"431","author":"Heimesaat","year":"2021","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alter, T., and Reich, F. (2021). Management Strategies for Prevention of Campylobacter Infections Through the Poultry Food Chain: A European Perspective. Fighting Campylobacter Infections: Towards a One Health Approach, Springer.","DOI":"10.1007\/978-3-030-65481-8_4"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mortensen, N., Jonasson, S.A., Lavesson, I.V., Emberland, K.E., Litleskare, S., Wensaas, K.-A., Rortveit, G., Langeland, N., and Hanevik, K. (2021). Characteristics of hospitalized patients during a large waterborne outbreak of Campylobacter jejuni in Norway. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0259407"},{"key":"ref_7","first-page":"1525","article-title":"Campylobacter enteritis","volume":"120","author":"Karmali","year":"1979","journal-title":"Can. Med. Assoc. J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Klein, G. (2017). Chapter 1\u2014Human campylobacteriosis. Campylobacter, Academic Press.","DOI":"10.1016\/B978-0-12-803623-5.00001-0"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.7883\/yoken.52.99","article-title":"Pathogenesis of Guillain-Barr\u00e9 and Miller Fisher syndromes subsequent to Campylobacter jejuni enteritis","volume":"52","author":"Yuki","year":"1999","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1136\/jcp.2006.046284","article-title":"Bickerstaff\u2019s brainstem encephalitis related to Campylobacter jejuni gastroenteritis","volume":"60","author":"Hussain","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MOG.0b013e3283413763","article-title":"Update on human Campylobacter jejuni infections","volume":"27","author":"Kirkpatrick","year":"2011","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.micinf.2009.07.004","article-title":"Sialylation of Campylobacter jejuni lipo-oligosaccharides is associated with severe gastro-enteritis and reactive arthritis","volume":"11","author":"Mortensen","year":"2009","journal-title":"Microbes Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1128\/IAI.00321-08","article-title":"The sialylated lipooligosaccharide outer core in Campylobacter jejuni is an important determinant for epithelial cell invasion","volume":"76","author":"Louwen","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mousavi, S., Bereswill, S., and Heimesaat, M.M. (2020). Novel Clinical Campylobacter jejuni Infection Models Based on Sensitization of Mice to Lipooligosaccharide, a Major Bacterial Factor Triggering Innate Immune Responses in Human Campylobacteriosis. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040482"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1136\/jcp.32.10.990","article-title":"Acute diarrhoea: Campylobacter colitis and the role of rectal biopsy","volume":"32","author":"Price","year":"1979","journal-title":"J. Clin. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tegtmeyer, N., Sharafutdinov, I., Harrer, A., Esmaeili, D.S., Linz, B., and Backert, S. (2021). Campylobacter Virulence Factors and Molecular Host\u2013Pathogen Interactions. Fighting Campylobacter Infections: Towards a One Health Approach, Springer.","DOI":"10.1007\/978-3-030-65481-8_7"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1128\/IAI.68.12.6535-6541.2000","article-title":"Campylobacter jejuni cytolethal distending toxin mediates release of interleukin-8 from intestinal epithelial cells","volume":"68","author":"Hickey","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1099\/mic.0.2008\/021279-0","article-title":"Campylobacter jejuni invade chicken LMH cells inefficiently and stimulate differential expression of the chicken CXCLi1 and CXCLi2 cytokines","volume":"154","author":"Larson","year":"2008","journal-title":"Microbiology"},{"key":"ref_19","first-page":"203","article-title":"Diarrheal mechanisms and the role of intestinal barrier dysfunction in Campylobacter infections","volume":"431","author":"Schulzke","year":"2021","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/mi.2017.78","article-title":"Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon","volume":"11","author":"Krug","year":"2018","journal-title":"Mucosal. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Haag, L.-M., Fischer, A., Otto, B., Plickert, R., K\u00fchl, A.A., G\u00f6bel, U.B., Bereswill, S., and Heimesaat, M.M. (2012). Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10\u2212\/\u2212 mice via Toll-like-receptor-2 and-4 signaling. PloS ONE, 7.","DOI":"10.1371\/journal.pone.0040761"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1053\/j.gastro.2011.09.042","article-title":"Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling","volume":"142","author":"Sun","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_23","first-page":"233","article-title":"Murine Models for the Investigation of Colonization Resistance and Innate Immune Responses in Campylobacter Jejuni Infections","volume":"431","author":"Mousavi","year":"2021","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41598-020-59890-8","article-title":"Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice","volume":"10","author":"Mousavi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.3389\/fimmu.2019.02094","article-title":"Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model","volume":"10","author":"Mousavi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13099-019-0343-4","article-title":"Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model","volume":"12","author":"Mousavi","year":"2020","journal-title":"Gut Pathog."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Escher, U., de S\u00e1, F.D.L., Peh, E., Schulzke, J.-D., Kittler, S., B\u00fccker, R., and Bereswill, S. (2020). Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study. Microorganisms, 8.","DOI":"10.3390\/microorganisms8121858"},{"key":"ref_28","first-page":"454","article-title":"Resveratrol prevents Campylobacter jejuni-induced leaky gut by restoring occludin and claudin-5 in the paracellular leak pathway","volume":"12","author":"Heimesaat","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mousavi, S., Weschka, D., Bereswill, S., and Heimesaat, M.M. (2021). Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10\u2212\/\u2212 Mice. Pathogens, 10.","DOI":"10.3390\/pathogens10010007"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Weschka, D., and Bereswill, S. (2021). Anti-Pathogenic and Immune-Modulatory Effects of Peroral Treatment with Cardamom Essential Oil in Acute Murine Campylobacteriosis. Microorganisms, 9.","DOI":"10.3390\/microorganisms9010169"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Mousavi, S., Weschka, D., Buczkowski, A., Schmidt, S., and Heimesaat, M.M. (2021). Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis-Results from a Preclinical Murine Intervention Study. Microorganisms, 9.","DOI":"10.3390\/microorganisms9040735"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Weschka, D., and Bereswill, S. (2021). Garlic Essential Oil as Promising Option for the Treatment of Acute Campylobacteriosis\u2014Results from a Preclinical Placebo-Controlled Intervention Study. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061140"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Kl\u00f8ve, S., Genger, C., Weschka, D., Giladi, E., Bereswill, S., and Gozes, I. (2020). Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis. Microorganisms, 8.","DOI":"10.3390\/microorganisms8060802"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Kl\u00f8ve, S., Genger, C., Weschka, D., Tamas, A., Reglodi, D., and Bereswill, S. (2020). Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice. Pathogens, 9.","DOI":"10.3390\/pathogens9100805"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13099-017-0168-y","article-title":"Amelioration of intestinal and systemic sequelae of murine Campylobacter jejuni infection by probiotic VSL#3 treatment","volume":"9","author":"Ekmekciu","year":"2017","journal-title":"Gut Pathog."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.3389\/fimmu.2019.02272","article-title":"Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota","volume":"10","author":"Heimesaat","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"19797","DOI":"10.1038\/s41598-019-56442-7","article-title":"Murine fecal microbiota transplantation lowers gastrointestinal pathogen loads and dampens pro-inflammatory immune responses in Campylobacter jejuni infected secondary abiotic mice","volume":"9","author":"Heimesaat","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/bcp.12793","article-title":"Activated charcoal for acute overdose: A reappraisal","volume":"81","author":"Juurlink","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1080\/03007995.2017.1416345","article-title":"Is there a role for charcoal in palliative diarrhea management?","volume":"34","author":"Senderovich","year":"2018","journal-title":"Curr. Med Res. Opin."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/039139889101400109","article-title":"Removal of endotoxin and cytokines by adsorbents and the effect of plasma protein binding","volume":"14","author":"Nagaki","year":"1991","journal-title":"Int. J. Artif. Organs"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","article-title":"Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii","volume":"177","author":"Heimesaat","year":"2006","journal-title":"J. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Fischer, A., Plickert, R., Haag, L.-M., Otto, B., Kuhl, A.A., Dasti, J.I., Zautner, A.E., Munoz, M., and Loddenkemper, C. (2011). Novel murine infection models provide deep insights into the \u201cmenage a trois\u201d of Campylobacter jejuni, microbiota and host innate immunity. PLoS ONE, 6.","DOI":"10.1371\/annotation\/5247af81-4595-44b7-9c3f-2e45ad85abfa"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1556\/EuJMI.3.2013.3.4","article-title":"Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice","volume":"3","author":"Heimesaat","year":"2013","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fcimb.2014.00077","article-title":"The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice","volume":"4","author":"Heimesaat","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_45","first-page":"4557","article-title":"A guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2017.12.023","article-title":"The octapetide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis","volume":"101","author":"Heimesaat","year":"2018","journal-title":"Peptides"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4315\/0362-028X-60.4.358","article-title":"Adsorption of cholera and heat-labile Escherichia coli enterotoxins by various adsorbents: An in vitro study","volume":"60","author":"Ramu","year":"1997","journal-title":"J. Food Prot."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/aem.53.4.777-781.1987","article-title":"Survival of selected bacterial species in sterilized activated carbon filters and biological activated carbon filters","volume":"53","author":"Rollinger","year":"1987","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1021\/acs.est.8b05024","article-title":"Effect of biochar on microbial growth: A metabolomics and bacteriological investigation in Escherichia coli","volume":"53","author":"Hill","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fcimb.2014.00137","article-title":"Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni","volume":"4","author":"Hofreuter","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/212941a0","article-title":"Effect of activated charcoal on the swarming of proteus","volume":"212","author":"Smith","year":"1966","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/jcm.23.3.456-459.1986","article-title":"Evaluation of a blood-free, charcoal-based, selective medium for the isolation of Campylobacter organisms from feces","volume":"23","author":"Karmali","year":"1986","journal-title":"J. Clin. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1128\/AAC.00039-13","article-title":"Oral DAV131, a charcoal-based adsorbent, inhibits intestinal colonization by \u03b2-lactam-resistant Klebsiella pneumoniae in cefotaxime-treated mice","volume":"57","author":"Grall","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1292\/jvms.63.281","article-title":"Adsorption effect of activated charcoal on enterohemorrhagic Escherichia coli","volume":"63","author":"Naka","year":"2001","journal-title":"J. Vet. Med. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00003246-199001000-00015","article-title":"Detoxification of plasma containing lipopolysaccharide by adsorption","volume":"18","author":"Bysani","year":"1990","journal-title":"Crit. Care Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1128\/aem.45.3.784-791.1983","article-title":"Production of superoxide and hydrogen peroxide in medium used to culture Legionella pneumophila: Catalytic decomposition by charcoal","volume":"45","author":"Hoffman","year":"1983","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.intimp.2016.10.023","article-title":"Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPK\u03b1 and downregulation of STAT3 and caspase 3 dependent apoptotic pathways","volume":"43","author":"Afrin","year":"2017","journal-title":"Int. Immunopharmacol."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/7\/1424\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:26Z","timestamp":1760163866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/7\/1424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":58,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["microorganisms9071424"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms9071424","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}