{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:56:01Z","timestamp":1789631761680,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The aim of this multicentre study was to determine the in vitro susceptibility to anti-anaerobic antibiotics of Gram-positive anaerobic cocci (GPAC) isolates responsible for invasive infections in humans. A total of 133 GPAC isolates were collected in nine French hospitals from 2016 to 2020. All strains were identified to the species level (MALDI-TOF mass spectrometry, 16S rRNA sequencing). Minimum inhibitory concentrations (MICs) of amoxicillin, piperacillin, cefotaxime, imipenem, clindamycin, vancomycin, linezolid, moxifloxacin, rifampicin, and metronidazole were determined by the reference agar dilution method. Main erm-like genes were detected by PCR. The 133 GPAC isolates were identified as follows: 10 Anaerococcus spp., 49 Finegoldia magna, 33 Parvimonas micra, 30 Peptoniphilus spp., and 11 Peptostreptococcus anaerobius. All isolates were susceptible to imipenem, vancomycin (except 3 P. micra), linezolid and metronidazole. All isolates were susceptible to amoxicillin and piperacillin, except for P. anaerobius (54% and 45% susceptibility only, respectively). MICs of cefotaxime widely varied while activity of rifampicin, and moxifloxacin was also variable. Concerning clindamycin, 31 were categorized as resistant (22 erm(A) subclass erm(TR), 7 erm(B), 1 both genes and 1 negative for tested erm genes) with MICs from 8 to &gt;32 mg\/L. Although GPACs are usually susceptible to drugs commonly used for the treatment of anaerobic infections, antimicrobial susceptibility should be evaluated in vitro.<\/jats:p>","DOI":"10.3390\/microorganisms9081665","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T21:45:06Z","timestamp":1628113506000},"page":"1665","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["In Vitro Antimicrobial Susceptibility Profiles of Gram-Positive Anaerobic Cocci Responsible for Human Invasive Infections"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-3131","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Gu\u00e9rin","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne Hospitali\u00e8re, CHU de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Dejoies","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne Hospitali\u00e8re, CHU de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-9882","authenticated-orcid":false,"given":"Nicolas","family":"Degand","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, CHU de Nice, F-06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Guet-Revillet","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie-Hygi\u00e8ne, H\u00f4pital Purpan, F-31059 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Janvier","sequence":"additional","affiliation":[{"name":"Service de Microbiologie et Hygi\u00e8ne Hospitali\u00e8re, H\u00f4pital d\u2019Instruction des Arm\u00e9es Saint-Anne, F-83800 Toulon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-8111","authenticated-orcid":false,"given":"St\u00e9phane","family":"Corvec","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie et des Contr\u00f4les Microbiologiques, CHU de Nantes, F-44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-9206","authenticated-orcid":false,"given":"Olivier","family":"Barraud","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie-Virologie-Hygi\u00e8ne, CHU Dupuytren, F-87042 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-0398","authenticated-orcid":false,"given":"Thomas","family":"Guillard","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie-Virologie-Hygi\u00e8ne Hospitali\u00e8re, H\u00f4pital Robert Debr\u00e9-CHU de Reims, F-51090 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Walewski","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, H\u00f4pitaux Universitaires de Paris Seine Denis (HUPSSD), Site Avicenne, AP-HP, F-93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Gallois","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Gustave Roussy, F-94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-9912","authenticated-orcid":false,"given":"Vincent","family":"Cattoir","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne Hospitali\u00e8re, CHU de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the GMC Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/CMR.11.1.81","article-title":"Gram-positive anaerobic cocci","volume":"11","author":"Murdoch","year":"1998","journal-title":"Clin. 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