{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:08Z","timestamp":1790517488070,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to estimate the disease burden of EV and PeV infections in Europe via establishment of standardized surveillance for hand, foot and mouth disease (HFMD) and respiratory and neurological infections caused by these viruses. We will also assess the sensitivity of assays implemented in the network of participating laboratories so that all EV and PeV types are adequately detected. Plan. The European Non-Polio Enterovirus Network (ENPEN) has developed standardized protocols for a prospective, multi-center and cross-sectional hospital-based pilot study. Protocols include guidance for diagnosis, case definition, detection, characterization and reporting of EV and PeV infections associated with HFMD and respiratory and neurological diseases. Over 30 sites from 17 European countries have already registered to this one pilot study, likely to be commenced in 2022. Benefits. This surveillance will allow European-wide comparison of data on EV and PeV infection. These data will also be used to determine the burden of EV and PeV infections, which is needed to guide the further prevention measures and policies.<\/jats:p>","DOI":"10.3390\/microorganisms9091827","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:49:51Z","timestamp":1630363791000},"page":"1827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe"],"prefix":"10.3390","volume":"9","author":[{"given":"Heli","family":"Harvala","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant, Microbiology Services, Colindale, London NW9 5BG, UK"},{"name":"Department of Infection, University College London (UCL), London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley S. M.","family":"Benschop","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment, 3721 MA Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Berginc","sequence":"additional","affiliation":[{"name":"Laboratory for Public Health Virology, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Midgley","sequence":"additional","affiliation":[{"name":"The WHO National Reference Laboratory for Poliovirus, Statens Serum Institute, DK-2300 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-7049","authenticated-orcid":false,"given":"Katja","family":"Wolthers","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-4700","authenticated-orcid":false,"given":"Peter","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Feeney","sequence":"additional","affiliation":[{"name":"Regional Virus Laboratory, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Bailly","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, National Reference Centre for Enteroviruses and Parechoviruses\u2013Associated Laboratory, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Mirand","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, National Reference Centre for Enteroviruses and Parechoviruses\u2013Associated Laboratory, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Nordsjaellands University Hospital, DK-3400 Hilleroed, Denmark"},{"name":"Department of Public Health and Department of International Health, University of Copenhagen, DK-1353 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the ENPEN Hospital-Based Surveillance Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","unstructured":"Gorbach, S.L., Bartlett, J.G., and Blacklow, N.R. 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