{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:16:08Z","timestamp":1788822968809,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation of the gastrointestinal tract. IBD includes Crohn\u2019s disease (CD) and ulcerative colitis (UC). CD can occur in any part of the gastrointestinal tract, whereas UC mainly occurs in the colon and rectum. We previously demonstrated that a novel exopolysaccharide (EPS) produced by a plant-derived bacterium, Lactobacillus paracasei IJH-SONE68, prevents and improves the inflammation in contact dermatitis model mice via oral administration. To evaluate the preventive effect of the EPS against other inflammatory diseases, in the present study, we employed dextran sulfate sodium (DSS)-induced UC model mice. The stool consistency, hematochezia, and colonic atrophy of the mice were improved by the orally administered EPS. We also evaluated the cytokine transcription. Overexpression of the mouse macrophage inflammatory protein 2 mRNA in the colon as a functional homolog of human interleukin-8 was decreased by the orally administered EPS. However, the expression of interleukin-10, which is known as an anti-inflammatory cytokine, was stimulated in the EPS-administrated group. Based on these results, we conclude that the IJH-SONE68-derived EPS is a promising lead material for the development of drugs useful in treating inflammatory diseases such as UC.<\/jats:p>","DOI":"10.3390\/microorganisms9112243","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:51:36Z","timestamp":1635465096000},"page":"2243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS\u2013Induced Ulcerative Colitis"],"prefix":"10.3390","volume":"9","author":[{"given":"Masafumi","family":"Noda","sequence":"first","affiliation":[{"name":"Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-3667","authenticated-orcid":false,"given":"Narandalai","family":"Danshiitsoodol","sequence":"additional","affiliation":[{"name":"Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3133-7154","authenticated-orcid":false,"given":"Keishi","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Hiroshima University Hospital, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan"},{"name":"Department of Clinical Pharmaceutical and Therapeutics, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical and Therapeutics, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan"},{"name":"Sone Farm Co., Ltd., Shinjuku, Shinjuku-ku, Tokyo 160-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2018","journal-title":"Lancet"},{"key":"ref_2","unstructured":"GBD 2017 Inflammatory Bowel Disease Collaborators (2020). The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol. Hepatol., 5, 17\u201330."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: Clinical aspects and established and evolving therapies","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.crohns.2011.10.004","article-title":"Anti-TNF-\u03b1 antibodies improve intestinal barrier function in Crohn\u2019s disease","volume":"6","author":"Noth","year":"2012","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ibd.21403","article-title":"Importance of disrupted intestinal barrier in inflammatory bowel diseases","volume":"17","author":"Salim","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/gut.2010.224154","article-title":"Guidelines for the management of inflammatory bowel disease in adults","volume":"60","author":"Mowat","year":"2011","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/DDDT.S11290","article-title":"Current and emerging drugs for the treatment of inflammatory bowel disease","volume":"5","author":"Triantafillidis","year":"2011","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1086\/523341","article-title":"Probiotics: Definition, sources, selection, and uses","volume":"46","author":"Sanders","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1248\/bpb.b16-00856","article-title":"Characterization of exopolysaccharides produced by thermophilic lactic acid bacteria isolated from tropical fruits of Thailand","volume":"40","author":"Panthavee","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jb\/mvy048","article-title":"A novel structure of exopolysaccharide produced by a plant-derived lactic acid bacterium Lactobacillus paracasei IJH-SONE68","volume":"164","author":"Noda","year":"2018","journal-title":"J. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1248\/bpb.b17-00840","article-title":"Characterization of the SN35N strain-specific exopolysaccharide encoded in the whole circular genome of a plant-derived Lactobacillus plantarum","volume":"41","author":"Noda","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1248\/cpb.33.642","article-title":"Activation of hyaluronidase by metallic salts and compound 48\/80, and inhibitory effect of anti-allergic agents on hyaluronidase","volume":"33","author":"Kakegawa","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1023\/A:1012592620347","article-title":"Inhibitory effects of microalgae on the activation of hyaluronidase","volume":"13","author":"Fujitani","year":"2001","journal-title":"J. Appl. Phycol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3358\/shokueishi.31.233","article-title":"Inhibitory effect of tea extracts on hyaluronidase","volume":"31","author":"Maeda","year":"1990","journal-title":"Shokuhin Eiseigaku Zashi"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Noda, M., Sultana, N., Hayashi, I., Fukamachi, M., and Sugiyama, M. (2019). Exopolysaccharide produced by Lactobacillus paracasei IJH-SONE68 prevents and improves the picryl chloride-induced contact dermatitis. Molecules, 24.","DOI":"10.3390\/molecules24162970"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0168-1605(98)00023-3","article-title":"Development of a growth medium suitable for exopolysaccharide production by Lactobacillus delbrueckii ssp. bulgaricus RR","volume":"40","author":"Kimmel","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00301845","article-title":"Carnitine: A novel compatible solute in Lactobacillus plantarum","volume":"162","author":"Kets","year":"1994","journal-title":"Arch. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1099\/mic.0.049148-0","article-title":"Lactobacillus S-layer protein inhibition of Salmonella-induced reorganization of the cytoskeleton and activation of MAPK signaling pathways in Caco-2 cells","volume":"157","author":"Li","year":"2011","journal-title":"Microbiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.3168\/jds.2018-15669","article-title":"Effect of fermented milk from Lactococcus lactis ssp. cremoris strain JFR1 on Salmonella invasion of intestinal epithelial cells","volume":"102","author":"Zhang","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_20","first-page":"3678","article-title":"Investigating intestinal inflammation in DSS-induced model of IBD","volume":"60","author":"Kim","year":"2012","journal-title":"J. Vis. Exp."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2307\/3001913","article-title":"Comparing individual means in the analysis of variance","volume":"5","author":"Tukey","year":"1949","journal-title":"Biometrics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0016-5085(90)90290-H","article-title":"A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice","volume":"98","author":"Okayasu","year":"1990","journal-title":"Gastroenterology"},{"key":"ref_24","first-page":"R72","article-title":"Relation of peroxidase activity in gut mucosa to inflammation","volume":"234","author":"Smith","year":"1978","journal-title":"Am. J. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0140-6736(77)90831-5","article-title":"An experiment to determine the active therapeutic moiety of sulphasalazine","volume":"2","author":"Khan","year":"1977","journal-title":"Lancet"},{"key":"ref_26","first-page":"CD000543","article-title":"Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis","volume":"8","author":"Murray","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_27","first-page":"CD000544","article-title":"Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis","volume":"8","author":"Murray","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1053\/j.gastro.2020.01.006","article-title":"AGA clinical practice guidelines on the management of moderate to severe ulcerative colitis","volume":"158","author":"Feuerstein","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.3748\/wjg.v22.i20.4794","article-title":"Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment","volume":"22","author":"Axelrad","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s10620-017-4574-2","article-title":"Use of tumor necrosis factor alpha inhibitors for inflammatory bowel disease patients with concurrent heart failure","volume":"62","author":"Jiang","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2249.1994.tb06047.x","article-title":"IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn\u2019s disease","volume":"96","author":"Mitsuyama","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence","volume":"133","author":"Acosta","year":"2008","journal-title":"Cell"},{"key":"ref_34","first-page":"13","article-title":"Interleukin-8 in gastrointestinal inflammation and malignancy: Induction and clinical consequences","volume":"8","author":"Cotton","year":"2016","journal-title":"Int. J. Interferon Cytokine Mediat. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3748\/wjg.v10.i5.620","article-title":"IL-10 and its related cytokines for treatment of inflammatory bowel disease","volume":"10","author":"Li","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng.221","article-title":"Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility","volume":"40","author":"Franke","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"Rennick","year":"1993","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10- deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses","volume":"98","author":"Berg","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI21404","article-title":"IL-23 is essential for T cell\u2013mediated colitis and promotes inflammation via IL-17 and IL-6","volume":"116","author":"Yen","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1084\/jem.20061082","article-title":"IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis","volume":"203","author":"Kullberg","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s10620-010-1286-2","article-title":"CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model","volume":"56","author":"Ogino","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.4049\/jimmunol.175.10.6900","article-title":"Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria","volume":"175","author":"Kamada","year":"2005","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3168\/jds.2015-10376","article-title":"Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1","volume":"99","author":"Makino","year":"2016","journal-title":"J. Dairy Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cyto.2007.01.003","article-title":"Effect of the oral administration of the exopolysaccharide produce by Lactobacillus kefiranofaciens on the gut mucosal immunity","volume":"36","author":"Vinderola","year":"2006","journal-title":"Cytokine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1002\/1521-4141(200211)32:11<3197::AID-IMMU3197>3.0.CO;2-1","article-title":"Blockade of CXCL10 protects mice from acute colitis and enhances crypt cell survival","volume":"32","author":"Sasaki","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1098\/rstb.1998.0246","article-title":"Stem cells in gastrointestinal epithelium: Numbers, characteristics and death","volume":"353","author":"Potten","year":"1998","journal-title":"Philos. Trans. R. Soc. Lond. B."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.cell.2016.06.003","article-title":"Colonic Crypts: Safe Haven from Microbial Products","volume":"165","author":"Snippert","year":"2016","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.270.5239.1203","article-title":"Inflammatory bowel diseases and adenomas in mice expressing a dominant negative N-cadherin","volume":"270","author":"Hermiston","year":"1995","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1101\/gad.10.8.985","article-title":"Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system","volume":"10","author":"Hermiston","year":"1996","journal-title":"Genes Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1053\/j.gastro.2007.02.001","article-title":"R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice","volume":"132","author":"Zhao","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Qi, K., Lv, J., Wu, J., and Xu, Z. (2017). Therapeutic effects of different doses of polyethylene glycosylated porcine glucagon-like peptide-2 on ulcerative colitis in male rats. BMC Gastroenterol., 17.","DOI":"10.1186\/s12876-017-0593-x"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1124\/jpet.103.051771","article-title":"GLP-2 and DSS glucagon-like peptide-2 and common therapeutics in a murine model of ulcerative colitis","volume":"306","author":"Brubaker","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/IAI.71.2.872-881.2003","article-title":"Disruption of epithelial barrier integrity by Salmonella enterica serovar Typhimurium requires geranylgeranylated proteins","volume":"71","author":"Tafazoli","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13099-019-0283-z","article-title":"Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA","volume":"11","author":"Harrer","year":"2019","journal-title":"Gut Pathog."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S1286-4579(01)01481-2","article-title":"Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria","volume":"3","author":"Freudenberg","year":"2001","journal-title":"Microb. Infect."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/IAI.01562-08","article-title":"Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes","volume":"77","author":"Rathinam","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mib.2003.12.008","article-title":"Living in the danger zone: Innate immunity to Salmonella","volume":"7","author":"Wick","year":"2004","journal-title":"Curr. Opin. Microb."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12149","DOI":"10.1074\/jbc.M109.070227","article-title":"Reconstitution of a functional toll-like receptor 5 binding site in Campylobacter jejuni flagellin","volume":"285","author":"Keestra","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.12703\/P6-97","article-title":"MyD88: A central player in innate immune signaling","volume":"6","author":"Deguine","year":"2014","journal-title":"F1000Prime Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling","volume":"7","author":"Bowie","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1016\/j.molimm.2006.12.021","article-title":"Molecular cloning of porcine RP105\/MD-1 involved in recognition of extracellular phosphopolysaccharides from Lactococcus lactis ssp. cremoris","volume":"44","author":"Tohno","year":"2007","journal-title":"Mol. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.3168\/jds.S0022-0302(06)72560-7","article-title":"Immunomodulatory effects of polysaccharides produced by Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1","volume":"89","author":"Makino","year":"2006","journal-title":"J. Dairy Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0168-1605(98)00030-0","article-title":"Phosphate group requirement for mitogenic activation of lymphocytes by an extracellular phosphopolysaccharide from Lactobacillus delbrueckii ssp. bulgaricus","volume":"40","author":"Kitazawa","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0168-1605(96)00968-3","article-title":"Induction of IFN-\u03b3 and IL-1\u03b1 production in macrophages stimulated with phosphopolysaccharide produced by Lactococcus lactis ssp. cremoris","volume":"31","author":"Kitazawa","year":"1996","journal-title":"Int. J. Food Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4109\/jslab.22.100","article-title":"Chemical and immunological characterization of extracellular polysaccharides produced by Lactobacillus plantarum No 14","volume":"22","author":"Hashiguchi","year":"2011","journal-title":"Jpn. J. Lact. Acid Bact."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1097\/MIB.0000000000001228","article-title":"Systematic review and meta-analysis: Fecal microbiota transplantation for treatment of active ulcerative colitis","volume":"23","author":"Narula","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1177\/2050640618780762","article-title":"Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: A systematic review and meta-analysis","volume":"6","author":"Ianiro","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gutjnl-2016-313017","article-title":"European consensus conference on faecal microbiota transplantation in clinical practice","volume":"66","author":"Cammarota","year":"2017","journal-title":"Gut"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cmet.2017.09.008","article-title":"Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition","volume":"26","author":"Kootte","year":"2017","journal-title":"Cell Metab."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Wang, S., Xu, M., Wang, W., Cao, X., Piao, M., Khan, S., Yan, F., Cao, H., and Wang, B. (2016). Systematic review: Adverse events of fecal microbiota transplantation. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161174"},{"key":"ref_72","unstructured":"FDA (2019). Important Safety Alert Regarding Use of Fecal Microbiota for Transplantation and Risk of Serious Adverse Reactions Due to Transmission of Multi-Drug Resistant Organisms."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Pab\u00f3n-Carrasco, M., Ramirez-Baena, L., Vilar-Palomo, S., Castro-M\u00e9ndez, A., Martos-Garc\u00eda, R., and Rodr\u00edguez-Gallego, I. (2020). Probiotics as a coadjuvant factor in active or quiescent inflammatory bowel disease of adults\u2014A meta-analytical study. Nutrients, 12.","DOI":"10.3390\/nu12092628"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/jam.14907","article-title":"The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009\u20132020","volume":"130","author":"Emamie","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"ref_75","first-page":"62","article-title":"Anti-metastatic effect of kefir grain components on Lewis lung carcinoma and highly metastatic B16 melanoma in mice","volume":"45","author":"Furukawa","year":"2020","journal-title":"J. Agric. Sci. Tokyo Univ. Agric."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10620-010-1362-7","article-title":"The effect of exopolysaccharide-producing probiotic strains on gut oxidative damage in experimental colitis","volume":"56","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12602-012-9110-2","article-title":"Immune modulation capability of exopolysaccharides synthesised by lactic acid bacteria and bifidobacteria","volume":"4","author":"Gueimonde","year":"2012","journal-title":"Probiotics Antimicrob. 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