{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:34:03Z","timestamp":1760236443543,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["680088 SCHISTO_PERSIST"],"award-info":[{"award-number":["680088 SCHISTO_PERSIST"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204820\/Z\/16\/Z"],"award-info":[{"award-number":["204820\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T003618\/1","EP\/R01437X\/"],"award-info":[{"award-number":["EP\/T003618\/1","EP\/R01437X\/"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P025447\/1"],"award-info":[{"award-number":["MR\/P025447\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Schistosoma mansoni is a parasite which causes significant public-health issues, with over 240 million people infected globally. In Uganda alone, approximately 11.6 million people are affected. Despite over a decade of mass drug administration in this country, hyper-endemic hotspots persist, and individuals who are repeatedly heavily and rapidly reinfected are observed. Human blood-type antigens are known to play a role in the risk of infection for a variety of diseases, due to cross-reactivity between host antibodies and pathogenic antigens. There have been conflicting results on the effect of blood type on schistosomiasis infection and pathology. Moreover, the effect of blood type as a potential intrinsic host factor on S. mansoni prevalence, intensity, clearance, and reinfection dynamics and on co-infection risk remains unknown. Therefore, the epidemiological link between host blood type and S. mansoni infection dynamics was assessed in three hyper-endemic communities in Uganda. Longitudinal data incorporating repeated pretreatment S. mansoni infection intensities and clearance rates were used to analyse associations between blood groups in school-aged children. Soil-transmitted helminth coinfection status and biometric parameters were incorporated in a generalised linear mixed regression model including age, gender, and body mass index (BMI), which have previously been established as significant factors influencing the prevalence and intensity of schistosomiasis. The analysis revealed no associations between blood type and S. mansoni prevalence, infection intensity, clearance, reinfection, or coinfection. Variations in infection profiles were significantly different between the villages, and egg burden significantly decreased with age. While blood type has proven to be a predictor of several diseases, the data collected in this study indicate that it does not play a significant role in S. mansoni infection burdens in these high-endemicity communities.<\/jats:p>","DOI":"10.3390\/microorganisms9122448","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T05:42:10Z","timestamp":1638250930000},"page":"2448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ABO Blood Groups Do Not Predict Schistosoma mansoni Infection Profiles in Highly Endemic Villages of Uganda"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-4374","authenticated-orcid":false,"given":"Rachel","family":"Francoeur","sequence":"first","affiliation":[{"name":"Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK"},{"name":"Welcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK"},{"name":"Faculty of Science and Engineering, Department of Biological Sciences, University of Chester, Chester CH1 4BJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Atuhaire","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala P.O. Box 1661, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala P.O. Box 1661, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-1207","authenticated-orcid":false,"given":"Moses","family":"Adriko","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala P.O. Box 1661, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Ajambo","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala P.O. Box 1661, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrina","family":"Nankasi","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala P.O. Box 1661, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Babayan","sequence":"additional","affiliation":[{"name":"Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-6318","authenticated-orcid":false,"given":"Poppy","family":"Lamberton","sequence":"additional","affiliation":[{"name":"Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK"},{"name":"Welcome Centre for Integrative Parasitology, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, W., and Yang, K. (2021). The Global Status and Control of Human Schistosomiasis: An Overview. Sino-African Cooperation for Schistosomiasis Control in Zanzibar, Springer.","DOI":"10.1007\/978-3-030-72165-7"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Trienekens, S.C., Faust, C.L., Meginnis, K., Pickering, L., Ericsson, O., Nankasi, A., Moses, A., Tukahebwa, E.M., and Lamberton, P.H. (2020). Impacts of host gender on Schistosoma mansoni risk in rural Uganda\u2014A mixed-methods approach. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008266"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4269\/ajtmh.19-0815","article-title":"Discovering, defining, and summarizing persistent hotspots in SCORE studies","volume":"103","author":"Kittur","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_4","first-page":"1","article-title":"Characteristics of persistent hotspots of Schistosoma mansoni in western C\u00f4te d\u2019Ivoire","volume":"13","author":"Bellai","year":"2020","journal-title":"Parasites Vectors"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4269\/ajtmh.19-0658","article-title":"Environmental predictors of schistosomiasis persistent hotspots following mass treatment with praziquantel","volume":"102","author":"Walker","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3389\/fimmu.2021.635869","article-title":"Schistosomiasis morbidity hotspots: Roles of the human host, the parasite and their interface in the development of severe morbidity","volume":"12","author":"Mawa","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/infdis\/jix496","article-title":"A persistent hotspot of Schistosoma mansoni infection in a five-year randomized trial of praziquantel preventative chemotherapy strategies","volume":"216","author":"Wiegand","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13071-018-2656-4","article-title":"Current epidemiological evidence for predisposition to high or low intensity human helminth infection: A systematic review","volume":"11","author":"Wright","year":"2018","journal-title":"Parasites Vectors"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1017\/S0022149X18001116","article-title":"ABO blood group antigens may be associated with increased susceptibility to schistosomiasis: A systematic review and meta-analysis","volume":"94","author":"Tiongco","year":"2018","journal-title":"J. Helminthol."},{"key":"ref_10","first-page":"708","article-title":"Transfusion biology and therapy","volume":"Volume 46","author":"Jefferys","year":"2005","journal-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1017\/S0022149X12000855","article-title":"The association between multiple intestinal helminth infections and blood group, anaemia and nutritional status in human populations from Dore Bafeno, southern Ethiopia","volume":"88","author":"Degarege","year":"2014","journal-title":"J. Helminthol."},{"key":"ref_12","first-page":"1216","article-title":"Hookworm Infection and ABO Blood Group among Children in Aba Metropolis, Abia State, Nigeria","volume":"34","author":"Wokem","year":"2016","journal-title":"World Appl. Sci. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110343","DOI":"10.1016\/j.mehy.2020.110343","article-title":"The potential use of ABO blood group system for risk stratification of COVID-19","volume":"145","author":"AbdelMassih","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pendu, J.L., Breiman, A., Rocher, J., Dion, M., and Ruvo\u00ebn-Clouet, N. (2021). ABO blood types and COVID-19: Spurious, anecdotal, or truly important relationships? A reasoned review of available data. Viruses, 13.","DOI":"10.3390\/v13020160"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zeng, X., Fan, H., Lu, D., Huang, F., Meng, X., Li, Z., Tang, M., Zhang, J., Liu, N., and Liu, Z. (2020). Association between ABO blood groups and clinical outcome of coronavirus disease 2019: Evidence from two cohorts. medRxiv.","DOI":"10.1101\/2020.04.15.20063107"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1038\/emm.2016.164","article-title":"Effect of blood type on anti-\u03b1-Gal immunity and the incidence of infectious diseases","volume":"49","author":"Alberdi","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_17","unstructured":"Daniels, G. (2008). Human Blood Groups, John Wiley & Sons."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00439-008-0530-8","article-title":"Evolutionary dynamics of the human ABO gene","volume":"124","author":"Calafell","year":"2008","journal-title":"Hum. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1101\/gr.082768.108","article-title":"Widespread balancing selection and pathogen-driven selection at blood group antigen genes","volume":"19","author":"Fumagalli","year":"2009","journal-title":"Genome Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/eji.200636129","article-title":"Virus recognition by specific natural antibodies and complement results in MHC I cross-presentation","volume":"37","author":"Baple","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_21","first-page":"81","article-title":"Association between the Rh blood group and the Covid-19 susceptibility","volume":"31","author":"Esref","year":"2020","journal-title":"Int. J. Hematol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmv.2147","article-title":"Association of dengue disease severity and blood group: A systematic review and meta-analysis","volume":"31","author":"Hashan","year":"2021","journal-title":"Rev. Med. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.4049\/jimmunol.140.9.3273","article-title":"Analysis of the anti-Schistosoma mansoni surface antibody response during murine infection and its potential contribution to protective immunity","volume":"140","author":"Ali","year":"1988","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1023\/A:1020634602161","article-title":"Schistosome glycoconjugates in host-parasite interplay","volume":"18","author":"Hokke","year":"2001","journal-title":"Glycoconj. J."},{"key":"ref_25","first-page":"181","article-title":"Acquisition of human blood group antigens by Schistosoma mansoni","volume":"26","author":"Goldring","year":"1976","journal-title":"Clin. Exp. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijpara.2009.10.002","article-title":"Exposed proteins of the Schistosoma japonicum tegument","volume":"40","author":"Mulvenna","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1074\/mcp.M500287-MCP200","article-title":"Proteins exposed at the adult schistosome surface revealed by biotinylation","volume":"5","author":"Braschi","year":"2006","journal-title":"Mol. Cell. Proteom."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2307\/3278461","article-title":"Schistosoma mansoni: Adsorption of human blood group A and B antigens by schistosomula","volume":"60","author":"Dean","year":"1974","journal-title":"J. Parasitol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exppara.2007.12.016","article-title":"Schistosoma mansoni: Chemoreception through N-acetyl-D-galactosamine-containing receptors in females offers insight into increased severity of schistosomiasis in individuals with blood group A","volume":"119","author":"Haseeb","year":"2008","journal-title":"Exp. Parasitol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2329-891X.1000196","article-title":"The Association between Abo Blood Groups and Intestinal Schistosomiasis among Masero Primary School Children in Sanja, Northwest Ethiopia","volume":"4","author":"Addisu","year":"2016","journal-title":"J. Trop. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0035-9203(77)90094-3","article-title":"A, B, O blood groups and clinical forms of schistosomiasis mansoni","volume":"71","author":"Camus","year":"1977","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_32","first-page":"245","article-title":"ABO blood groups in bilharzial hepatic fibrosis","volume":"51","author":"Khattab","year":"1968","journal-title":"J. Egypt. Med. Assoc."},{"key":"ref_33","first-page":"370","article-title":"ABO blood group and late schistosomiasis japonica","volume":"96","author":"Wang","year":"1983","journal-title":"Chin. Med. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0001-706X(97)00671-2","article-title":"Schistosomiasis infection in relation to the ABO blood groups among school children in Zimbabwe","volume":"65","author":"Ndamba","year":"1997","journal-title":"Acta Trop."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-3024.1979.tb00701.x","article-title":"Distribution of blood groups and secretor status in schistosomiasis","volume":"1","author":"Trangle","year":"1979","journal-title":"Parasite Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2307\/3276629","article-title":"ABO and Rh. blood groups from patients with hepatosplenic schistosomiasis mansoni","volume":"53","author":"Katz","year":"1967","journal-title":"J. Parasitol."},{"key":"ref_37","first-page":"179","article-title":"ABO blood groups in malaria and schistosomiasis haematobium","volume":"39","author":"Kassim","year":"1982","journal-title":"Acta Trop."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0001-706X(93)90009-Z","article-title":"Diagnostic techniques in schistosomiasis control. A review","volume":"52","author":"Feldmeier","year":"1993","journal-title":"Acta Trop."},{"key":"ref_39","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni","volume":"14","author":"Katz","year":"1972","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"378","DOI":"10.32614\/RJ-2017-066","article-title":"glmmTMB Balances Speed and Flexibility Among Packages for Zero-inflated Generalized Linear Mixed Modeling","volume":"9","author":"Brooks","year":"2017","journal-title":"R J."},{"key":"ref_41","unstructured":"R Development Core Team (2018). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Version 3.5.2."},{"key":"ref_42","unstructured":"Hartig, F. (2021, November 26). DHARMa: Residual Diagnostics for Hierarchical (Multi-Level\/Mixed) Regression Models. R Package Version 0.2. Available online: https:\/\/cran.r-project.org\/web\/packages\/DHARMa\/vignettes\/DHARMa.html."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Jahanpour, O., Pyuza, J.J., Ntiyakunze, E.O., Mremi, A., and Shao, E.R. (2017). ABO and Rhesus blood group distribution and frequency among blood donors at Kilimanjaro Christian Medical Center, Moshi, Tanzania. BMC Res. Notes, 10.","DOI":"10.1186\/s13104-017-3037-3"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Apecu, R.O., Mulogo, E.M., Bagenda, F., and Byamungu, A. (2016). ABO and Rhesus (D) blood group distribution among blood donors in rural south western Uganda: A retrospective study. BMC Res. Notes, 9.","DOI":"10.1186\/s13104-016-2299-5"},{"key":"ref_45","unstructured":"De Onis, M. (2006). WHO Child Growth Standards, WHO."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Adriko, M., Faust, C.L., Carruthers, L.V., Moses, A., Tukahebwa, E.M., and Lamberton, P.H. (2018). Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda, due to the absence of treatment opportunities, rather than systematic non-compliance. Trop. Med. Infect. Dis., 3.","DOI":"10.3390\/tropicalmed3040111"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Clark, J., Arinaitwe, M., Nankasi, A., Faust, C.L., Moses, A., Ajambo, D., Besigye, F., Atuhaire, A., Wamboko, A., and Carruthers, L. (2021). Reconciling egg-and antigen-based estimates of Schistosoma mansoni clearance and reinfection: A modelling study. Clin. Infect. Dis., ciab679.","DOI":"10.1093\/cid\/ciab679"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4269\/ajtmh.16-0728","article-title":"More poop, more precision: Improving epidemiologic surveillance of soil-transmitted helminths with multiple fecal sampling using the Kato\u2013Katz technique","volume":"97","author":"Liu","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Abla, N., Keiser, J., Vargas, M., Reimers, N., Haas, H., and Spangenberg, T. (2017). Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005942"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.actatropica.2008.09.016","article-title":"The effect of the number of stool samples on the observed prevalence and the infection intensity with Schistosoma mansoni among a population in an area of low transmission","volume":"108","author":"Enk","year":"2008","journal-title":"Acta Trop."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.actatropica.2004.06.011","article-title":"Variations in helminth faecal egg counts in Kato\u2013Katz thick smears and their implications in assessing infection status with Schistosoma mansoni","volume":"92","author":"Berhe","year":"2004","journal-title":"Acta Trop."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1365-3024.2010.01235.x","article-title":"Circulating cytokine levels and antibody responses to human Schistosoma haematobium: IL-5 and IL-10 levels depend upon age and infection status","volume":"32","author":"Milner","year":"2010","journal-title":"Parasite Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1086\/589511","article-title":"Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population","volume":"198","author":"Mutapi","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mohammed, M.K., Halaly, S., Awadalla, H., Abdelrahman, A., and Balla, S. (2018). Prevalence, risk factors and effect of urinary schistosomiasis on academic performance of school children Age 6\u201315 years in Asalaya locality, White Nile State, Sudan 2017. J. Adv. Med. Med. Res., 1\u20137.","DOI":"10.9734\/JAMMR\/2018\/46471"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mitchell, K.M., Mutapi, F., Mduluza, T., Midzi, N., Savill, N.J., and Woolhouse, M.E.J. (2014). Predicted impact of mass drug administration on the development of protective immunity against Schistosoma haematobium. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003059"},{"key":"ref_57","first-page":"1","article-title":"Prevalence and intensity of urinary schistosomiasis in Abarma village, Gusau, Nigeria: A preliminary investigation","volume":"7","author":"Bala","year":"2012","journal-title":"Sci. World J."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/12\/2448\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:36:44Z","timestamp":1760168204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/12\/2448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,27]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["microorganisms9122448"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms9122448","relation":{},"ISSN":["2076-2607"],"issn-type":[{"type":"electronic","value":"2076-2607"}],"subject":[],"published":{"date-parts":[[2021,11,27]]}}}