{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:24:17Z","timestamp":1764433457940,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-34-70051"],"award-info":[{"award-number":["20-34-70051"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The sulphate-reducing bacteria (SRB) of genus Desulfovibrio are a group of prokaryotes associated with autism spectrum disorders (ASD). The connection between the elevated numbers of Desulfovibrio in the gut of children with ASD compared with healthy children remains unresolved. A conceivable consequence of SRB overgrowth in the gut is the conversion of bioavailable iron into low-soluble crystalline iron sulphides, causing iron deficiency in the organism. In this study, we report the draft genome sequence and physiological features of the first cultivable isolate from a patient with ASD, Desulfovibrio desulfuricans strain AY5.The capability of the strain to produce crystalline iron sulphides was studied under different pH conditions. The most notable greigite(Fe3S4) and pyrite (FeS2) formation was revealed at pH 6.0, which suggests that the iron loss due to insoluble sulphide formation may occur in the proximal part of the gastrointestinal tract. Strain AY5 was adapted to grow under nitrogen-limiting conditions by N2 fixation. The urease found in the strain\u2019s genome may play a role in resistance to acidic pH.<\/jats:p>","DOI":"10.3390\/microorganisms9122558","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T01:29:33Z","timestamp":1639358973000},"page":"2558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Desulfovibrio desulfuricans AY5 Isolated from a Patient with Autism Spectrum Disorder Binds Iron in Low-Soluble Greigite and Pyrite"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-2224","authenticated-orcid":false,"given":"Olga V.","family":"Karnachuk","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga P.","family":"Ikkert","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5901-8665","authenticated-orcid":false,"given":"Marat R.","family":"Avakyan","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-4628","authenticated-orcid":false,"given":"Yurii V.","family":"Knyazev","sequence":"additional","affiliation":[{"name":"Kirensky Institute of Physics, 660036 Krasnoyarsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"N.Volochaev","sequence":"additional","affiliation":[{"name":"Kirensky Institute of Physics, 660036 Krasnoyarsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viacheslav S.","family":"Zyusman","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasily L.","family":"Panov","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaly V.","family":"Kadnikov","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-8757","authenticated-orcid":false,"given":"Andrey V.","family":"Mardanov","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1456-1832","authenticated-orcid":false,"given":"Nikolai V.","family":"Ravin","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13643-019-1061-1","article-title":"Prevalence and Comorbidity of Autism Spectrum Disorder in Spain: Study Protocol for a Systematic Review and Meta-Analysis of Observational Studies","volume":"8","author":"Ridao","year":"2019","journal-title":"Syst. 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