{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:25Z","timestamp":1787029045061,"version":"build-2736575974"},"reference-count":15,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JYLAG, GAFFI","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Among people with HIV, histoplasmosis represents an important cause of mortality. Previous studies provided estimates of the disease incidence. Here, we compared those estimates with the results obtained from a screening program implemented in Guatemala, which included histoplasmosis detection for people with HIV. To compare the results of this program with previous estimations, a literature search was performed and reports concerning histoplasmosis incidence were analyzed. The screening program enrolled 6366 patients. The overall histoplasmosis incidence in the screening program was 7.4%, which was almost double that estimated in previous studies. From 2017 to 2019, the screening program showed an upward trend in histoplasmosis cases from 6.5% to 8.8%. Histoplasmosis overall mortality among those who were newly HIV diagnosed showed a decrease at 180 days from 32.8% in 2017 to 21.2% in 2019. The screening approach using rapid diagnostic assays detects histoplasmosis cases more quickly, allowing a specific treatment to be administered, which decreases the mortality of the disease. Therefore, the use of these new techniques, especially in endemic areas of histoplasmosis, must be implemented.<\/jats:p>","DOI":"10.3390\/microorganisms9122596","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T21:32:40Z","timestamp":1639690360000},"page":"2596","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6176-0052","authenticated-orcid":false,"given":"Narda","family":"Medina","sequence":"first","affiliation":[{"name":"Asociaci\u00f3n de Salud Integral, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Rodriguez-Tudela","sequence":"additional","affiliation":[{"name":"Global Action Fund for Fungal Infections, 01564 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n de Salud Integral, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-4136","authenticated-orcid":false,"given":"Luis R.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n de Salud Integral, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-1388","authenticated-orcid":false,"given":"Osmar","family":"Gamboa","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n de Salud Integral, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-3632","authenticated-orcid":false,"given":"Oscar","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Familiar \u201cLuis \u00c1ngel Garc\u00eda\u201d, Hospital General San Juan de Dios, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Familiar \u201cLuis \u00c1ngel Garc\u00eda\u201d, Hospital General San Juan de Dios, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-7413","authenticated-orcid":false,"given":"Eduardo","family":"Arathoon","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n de Salud Integral, Guatemala City 01001, Guatemala"},{"name":"Cl\u00ednica Familiar \u201cLuis \u00c1ngel Garc\u00eda\u201d, Hospital General San Juan de Dios, Guatemala City 01001, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-2251","authenticated-orcid":false,"given":"David W.","family":"Denning","sequence":"additional","affiliation":[{"name":"Global Action Fund for Fungal Infections, 01564 Geneva, Switzerland"},{"name":"The National Aspergillosis Centre, University Hospital of South Manchester, Manchester M23 9LT, UK"},{"name":"Manchester Academic Health Science Centre, School of Medicine, The University of Manchester, Manchester M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-4405","authenticated-orcid":false,"given":"Ana","family":"Alastruey-Izquierdo","sequence":"additional","affiliation":[{"name":"Global Action Fund for Fungal Infections, 01564 Geneva, Switzerland"},{"name":"Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","unstructured":"PAHO (2020). 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Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4269\/ajtmh.1960.9.518","article-title":"The Distribution of Histoplasmin Sensitivity in Guatemala","volume":"9","author":"Taylor","year":"1960","journal-title":"Am. J. Trop Med. Hyg."},{"key":"ref_15","unstructured":"Programa Nacional de Prevenci\u00f3n y Control de ITS VIH y SIDA (2019). 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