{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:57:18Z","timestamp":1789412238527,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T00:00:00Z","timestamp":1221004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, 1H- and 13C-NMR data and by elemental analysis.<\/jats:p>","DOI":"10.3390\/molecules13092126","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T16:35:42Z","timestamp":1222878942000},"page":"2126-2135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones"],"prefix":"10.3390","volume":"13","author":[{"given":"Olcay","family":"Bekircan","sequence":"first","affiliation":[{"name":"Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Bektas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2008,9,10]]},"reference":[{"key":"ref_1","first-page":"991","article-title":"Synthesis, biological and thermal properties of schiff bases of bisphenol-C","volume":"11","author":"Karia","year":"1999","journal-title":"Asian J. 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