{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:33:54Z","timestamp":1791920034152,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T00:00:00Z","timestamp":1231372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>There is an urgent need for novel and improved drugs against several tropical diseases caused by protozoa. The marine sponge (Agelas sp.) metabolite agelasine D, as well as other agelasine analogs and related structures were screened for inhibitory activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and T. cruzi, as well as for toxicity against MRC-5 fibroblast cells. Many compounds displayed high general toxicity towards both the protozoa and MRC-5 cells. However, two compounds exhibited more selective inhibitory activity against L. infantum (IC50 <\/jats:p>","DOI":"10.3390\/molecules14010279","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T06:00:18Z","timestamp":1231394418000},"page":"279-288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Screening of Agelasine D and Analogs for Inhibitory Activity against Pathogenic Protozoa; Identification of Hits for Visceral Leishmaniasis and Chagas Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Anders","family":"Vik","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Oslo, P.O.Box 1033, Blindern, N-0315 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Proszeny\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oslo, P.O.Box 1033, Blindern, N-0315 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Vermeersch","sequence":"additional","affiliation":[{"name":"University of Antwerp, Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Universiteitsplein 1, B-2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cos","sequence":"additional","affiliation":[{"name":"University of Antwerp, Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Universiteitsplein 1, B-2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Maes","sequence":"additional","affiliation":[{"name":"University of Antwerp, Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Universiteitsplein 1, B-2610 Antwerp, Belgium"},{"name":"Institute for Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise-Lotte","family":"Gundersen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oslo, P.O.Box 1033, Blindern, N-0315 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cbpa.2007.05.038","article-title":"Drug discovery for malaria: a very challenging and timely endeavor","volume":"11","author":"Gelb","year":"2007","journal-title":"Curr. 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