{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:49:20Z","timestamp":1775004560029,"version":"3.50.1"},"reference-count":21,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T00:00:00Z","timestamp":1250726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The glycosylation of \u03b1- and \u03b4-tocopherols using Klebsiella pneumoniae and cyclodextrin glucanotransferase (CGTase) was investigated. K. pneumoniae converted \u03b1- and \u03b4-tocopherols into the corresponding \u03b2-glucosides in 10 and 8% yield, respectively. CGTase glycosylated \u03b1-tocopheryl \u03b2-glucoside to \u03b1-tocopheryl \u03b2-maltoside (51%) and \u03b1-tocopheryl \u03b2-maltotrioside (35%). On the other hand, \u03b4-tocopheryl \u03b2-glucoside was converted into the corresponding \u03b2-maltoside (45%) and \u03b2-maltotrioside (29%) by CGTase. The \u03b2-glucoside of \u03b1-tocopherol, and \u03b2-glucoside and \u03b2-maltoside of \u03b4-tocopherol showed inhibitory effects on IgE antibody production and on histamine release from rat peritoneal mast cells.<\/jats:p>","DOI":"10.3390\/molecules14083106","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T16:36:45Z","timestamp":1250786205000},"page":"3106-3114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Production of \u03b2-Maltooligosaccharides of \u03b1- and \u03b4-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents"],"prefix":"10.3390","volume":"14","author":[{"given":"Kei","family":"Shimoda","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2009,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.56.1458.650","article-title":"On the existence of a hitherto unrecognized dietary factor essential for reproduction","volume":"56","author":"Evans","year":"1922","journal-title":"Science"},{"key":"ref_2","first-page":"54","article-title":"Vitamin E is nature\u2019s master antioxidant","volume":"1","author":"Packer","year":"1994","journal-title":"Sci. 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