{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:01:28Z","timestamp":1790352088876,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T00:00:00Z","timestamp":1251331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Snakebite envenomations cause severe local tissue necrosis and the venom metalloproteinases are thought to be the key toxins involved. In this study, the ethanolic extract from seed kernels of Thai mango (Mangifera indica L. cv. \u2018Fahlun\u2019) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent and dose\u2212dependent inhibitory effects on the caseinolytic and fibrinogenolytic activities of Malayan pit viper and Thai cobra venoms in in vitro tests. molecular docking studies revealed that the binding orientations of the phenolic principles were in the binding pockets of snake venom metalloproteinases (SVMPs). The phenolic principles could form hydrogen bonds with the three histidine residues in the conserved zinc\u2212binding motif and could chelate the Zn2+ atom of the SVMPs, which could potentially result in inhibition of the venom enzymatic activities and thereby inhibit tissue necrosis.<\/jats:p>","DOI":"10.3390\/molecules14093198","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T06:01:14Z","timestamp":1251352874000},"page":"3198-3213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Molecular Docking Studies and Anti\u2212Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract"],"prefix":"10.3390","volume":"14","author":[{"given":"Pimolpan","family":"Pithayanukul","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiraporn","family":"Leanpolchareanchai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patchreenart","family":"Saparpakorn","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4269\/ajtmh.1986.35.173","article-title":"ELISA confirmation of acute and past envenoming by the monocellate Thai cobra (Naja kaouthia)","volume":"35","author":"Viravan","year":"1986","journal-title":"Am. 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