{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:20:44Z","timestamp":1791174044336,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32\/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an \u03b1,\u03b2-unsaturated \u03b3-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.<\/jats:p>","DOI":"10.3390\/molecules14093621","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T11:05:18Z","timestamp":1253185518000},"page":"3621-3661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues"],"prefix":"10.3390","volume":"14","author":[{"given":"Naoto","family":"Kojima","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1021\/np800191t","article-title":"Paw paw and cancer: Annonaceous acetogenins from discovery to commercial products","volume":"71","author":"McLaughlin","year":"2008","journal-title":"J. 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