{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:02:43Z","timestamp":1788588163721,"version":"build-2803163510"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T00:00:00Z","timestamp":1260489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against emergent and re-emergent human and cattle infectious diseases (AIDS, hepatitis B and C, tuberculosis, bovine viral diarrhea). In particular, these compounds were evaluated in vitro against representatives of different virus classes, such as a HIV-1 (Retrovirus), a HBV (Hepadnavirus) and the single-stranded RNA+ viruses Yellow fever virus (YFV) and Bovine viral diarrhea virus (BVDV), both belonging to the Flaviridae. Compounds 2c, 2g and 3d showed a modest activity against CVB-2. The molecular structures of the starting imide 1 and one of propyl-piperazine derivatives, 3b, have been determined by an X-ray crystallography study.<\/jats:p>","DOI":"10.3390\/molecules14125189","type":"journal-article","created":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T11:33:01Z","timestamp":1260531181000},"page":"5189-5202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione"],"prefix":"10.3390","volume":"14","author":[{"given":"Jerzy","family":"Kossakowski","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, Medical University, 3 Oczki Str., 02-007 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Pakosinska-Parys","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Medical University, 3 Oczki Str., 02-007 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Struga","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Medical University, 3 Oczki Str., 02-007 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Dybala","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Koziol","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"La Colla","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042, Monserrato, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Ester","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042, Monserrato, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ibba","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042, Monserrato, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Collu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042, Monserrato, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Loddo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042, Monserrato, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2009,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nrd937","article-title":"Hepatitis C therapeutics: Current status and emerging strategies","volume":"1","author":"Tan","year":"2002","journal-title":"Nat. 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