{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:44:51Z","timestamp":1790779491090,"version":"4.1.0"},"reference-count":271,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T00:00:00Z","timestamp":1265760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Huntington\u2019s disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study.<\/jats:p>","DOI":"10.3390\/molecules15020878","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T11:29:30Z","timestamp":1265801370000},"page":"878-916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":189,"title":["3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington\u2019s Disease: Past, Present and Future"],"prefix":"10.3390","volume":"15","author":[{"given":"Isaac","family":"T\u00fanez","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, Av. Men\u00e9ndez Pidal s\/n, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Tasset","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, Av. Men\u00e9ndez Pidal s\/n, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"P\u00e9rez-De La Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Amino\u00e1cidos Excitadores, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda \u201cManuel Velasco Su\u00e1rez\u201d, M\u00e9xico D.F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Amino\u00e1cidos Excitadores, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda \u201cManuel Velasco Su\u00e1rez\u201d, M\u00e9xico D.F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2310\/7010.2006.00055","article-title":"Clinical characteristics of childhood-onset (juvenile) Huntington disease: Report of 12 patients and review of the literature","volume":"21","author":"Afifi","year":"2006","journal-title":"J. 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