{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:54:02Z","timestamp":1775152442160,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T00:00:00Z","timestamp":1268352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4\u201332 \u03bcg\/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on \u03b1-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding \u03b1-toxin) in S. aureus, resulting in a reduction of \u03b1-toxin secretion and, thus, hemolytic activities.<\/jats:p>","DOI":"10.3390\/molecules15031679","type":"journal-article","created":{"date-parts":[[2010,3,14]],"date-time":"2010-03-14T13:26:04Z","timestamp":1268573164000},"page":"1679-1689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Influence of Magnolol on the Secretion of \u03b1-Toxin by Staphylococcus aureus"],"prefix":"10.3390","volume":"15","author":[{"given":"Hua","family":"Xiang","sequence":"first","affiliation":[{"name":"Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Zhang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Shuai","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Heilongjiang August First Agricultural University, Daqing, Heilongjiang 163319, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jie","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangshu 225009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Ming","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2010,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1128\/AAC.50.4.1463-1469.2006","article-title":"Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility","volume":"50","author":"Meiller","year":"2006","journal-title":"Antimicrob. 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