{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:30:41Z","timestamp":1783996241996,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An efficient one-pot method to generate structurally diverse and medicinally interesting pyrazolone derivatives in good to excellent yields of 51\u201398% under microwave irradiation and solvent-free conditions has been developed.<\/jats:p>","DOI":"10.3390\/molecules15053593","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T11:13:22Z","timestamp":1274094802000},"page":"3593-3601","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions"],"prefix":"10.3390","volume":"15","author":[{"given":"Ruoqun","family":"Ma","sequence":"first","affiliation":[{"name":"School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China"},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China"},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"},{"name":"Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China"},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2165\/00003495-198600324-00006","article-title":"Pyrazolone derivatives","volume":"32","author":"Brogden","year":"1986","journal-title":"Drugs"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1016\/j.bmc.2009.05.058","article-title":"Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones","volume":"17","author":"Castagnolo","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1016\/j.tetlet.2009.09.047","article-title":"Microwave-assisted organocatalytic multicomponent Knoevenagel\/hetero Diels-Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles","volume":"50","author":"Radi","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref_4","first-page":"695","article-title":"Synthesis and fungitoxicity of different 2-pyrazolin-5-one Mannich bases","volume":"58","author":"Mitra","year":"1981","journal-title":"J. Indian Chem. Soc."},{"key":"ref_5","first-page":"165","article-title":"Synthesis and antifubgal activity of some 4-arylmethylene derivatives of substituted pyrazolones","volume":"68","author":"Singh","year":"1991","journal-title":"J. Indian Chem. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1016\/j.bmcl.2008.05.117","article-title":"Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors","volume":"18","author":"Moreau","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_7","first-page":"113","article-title":"Synthesis of 1-(substituted) 4-arylhydrazono-3-methyl-2-pyrazolin-5-ones as potential antiinflammatory agents","volume":"2","author":"Tantawy","year":"1988","journal-title":"Alexandria, M. E. J. Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jmgm.2009.04.006","article-title":"Pharmacophore and docking-based combined in-silico study of KDR inhibitors","volume":"28","author":"Pasha","year":"2009","journal-title":"J. Mol. Graph. Model."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1016\/j.bmcl.2008.09.027","article-title":"Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation","volume":"18","author":"Deng","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/ardp.200700157","article-title":"Synthesis and molluscicidal activity of new chromene and pyrano[2,3-c]pyrazole derivatives","volume":"340","author":"Abdelrazek","year":"2007","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1023\/B:COHC.0000014412.48911.60","article-title":"Azines and their acyclic derivatives as transferers of one-carbon fragment in reactions with pyrazolones","volume":"39","author":"Azev","year":"2003","journal-title":"Chem. Heterocycl. Comp."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1055\/s-1997-978","article-title":"A highly diastereoselective intramolecular hetero Diels-Alder approach towards tetracyclic pyrazoles","volume":"10","author":"Ceulemans","year":"1997","journal-title":"Synlett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3987\/COM-03-S20","article-title":"Transformations of alkyl (5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetates into 5-heteroaryl-3-OXO-2-phenyl-3,5-dihydro-2H-pyrazolo[4,3-c]pyridine-7- carboxylates","volume":"61","author":"Bevk","year":"2003","journal-title":"Heterocycles"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3987\/COM-04-10046","article-title":"Synthesis and NMR spectroscopic investigations with 3-amino-, 3-hydroxy-, and 3-methoxy-4-acyl-1-phenyl-2-pyrazolin-5-ones","volume":"63","author":"Holzer","year":"2004","journal-title":"Heterocycles"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ardp.19863190106","article-title":"Antiviral agents. XXVII: Aminomethynylation of 5-oxo-2-pyrazoline-3-carboxylic acid derivatives","volume":"319","author":"Kreutzberger","year":"1986","journal-title":"Arch. Pharm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1021\/ja01155a095","article-title":"The cyanine dye series. XI. The merocyanines","volume":"73","author":"Brooker","year":"1951","journal-title":"J. Am. Chem. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/cber.188401701152","article-title":"Einwirkung von Acetessigester auf Hydrazinchinizinderivate","volume":"17","author":"Knorr","year":"1884","journal-title":"Chem. Ber."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jlac.18862360303","article-title":"Synthetische Versuche mit dem Acetessigester. II. Mittheilung: Ueberf\u00fchrung des Diacetbernsteins\u00e4ureesters und des Acetessigesters in Pyrrolderivate","volume":"236","author":"Knorr","year":"1886","journal-title":"Ann. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1021\/ol035226w","article-title":"One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines","volume":"5","author":"Wu","year":"2003","journal-title":"Org. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1002\/anie.200400655","article-title":"Synthetic methods. Controlled microwave heating in modern organic synthesis","volume":"43","author":"Kappe","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tet.2004.10.042","article-title":"Improvement in the synthesis of metallophthalocyanines using microwave irradiation","volume":"61","author":"Burczyk","year":"2005","journal-title":"Tetrahedron"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1039\/b600031b","article-title":"Zeolite catalyzed acylation of alcohols and amines with acetic acid under microwave irradiation","volume":"8","author":"Narender","year":"2006","journal-title":"Green Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1039\/B815717K","article-title":"Microwave-assisted cycloaddition reactions","volume":"39","author":"Appukkuttan","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4155\/fmc.09.144","article-title":"Recent applications of microwave irradiation to medicinal chemistry","volume":"2","author":"Alcazar","year":"2010","journal-title":"Future Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2174\/138527210790231892","article-title":"Microwave-Assisted Multicomponent Reactions in the Heterocyclic Chemistry","volume":"14","author":"Jiang","year":"2010","journal-title":"Curr. Org. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1016\/j.tetlet.2009.09.047","article-title":"Microwave-assisted organocatalytic multicomponent Knoevenagel\/hetero Diels-Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles","volume":"50","author":"Radi","year":"2009","journal-title":"Tetrahedron Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/15\/5\/3593\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:02:27Z","timestamp":1760220147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/15\/5\/3593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,17]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5]]}},"alternative-id":["15053593"],"URL":"https:\/\/doi.org\/10.3390\/molecules15053593","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,17]]}}}