{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:20:23Z","timestamp":1784845223079,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T00:00:00Z","timestamp":1277337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study the effects of an aqueous suspension of a commercial preparation of the mushroom Coprinus comatus on oxidative stress induced in rats by alloxane and carbon tetrachloride was examined. The effects were estimated from changes in the biochemical parameters (xanthine oxidase, glutathione peroxidase and catalase activity, reduced glutathione content, and extent of lipid peroxidation) of liver homogenate as well as histological changes in the liver of the rats treated with alloxane and carbon tetrachloride. Two screening doses of alloxane sufficient to induce diabetes in rats did not have any significant effect on the examined biochemical parameters of liver homogenate or on the cytoarchitectonics of liver cross-sections. Treatment with carbon tetrachloride resulted in a significant increase in the intensity of lipid peroxidation and peroxydasis activity, as well as with decrease in catalase activity. Certain changes in liver cross sections were detected, such is lymphocyte infiltration of dilated sinusoid capillaries. Administration of Coprinus comatus suspension thus showed antioxidative potential, evidenced by an increase of antioxidative status of liver homogenate and prevention of histological changes in liver cross sections.<\/jats:p>","DOI":"10.3390\/molecules15074564","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T11:03:23Z","timestamp":1277377403000},"page":"4564-4571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Anti-Oxidative Activity of An Aqueous Suspension of Commercial Preparation of The Mushroom Coprinus comatus"],"prefix":"10.3390","volume":"15","author":[{"given":"Mira","family":"Popovi\u0107","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u0161a","family":"Vukmirovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Clinical Pharmacology, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neboj\u0161a","family":"Stilinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Clinical Pharmacology, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"\u010capo","sequence":"additional","affiliation":[{"name":"Department of Histology, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Jakovljevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Clinical Pharmacology, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1271\/bbb.70280","article-title":"Free-Radical scavenging activity of submerged micelium extracts from higher basidomycetes mushrooms","volume":"12","author":"Asatiani","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1039\/b402985m","article-title":"Natural products to drugs: natural product derived compounds in Clinical trials","volume":"22","author":"Butler","year":"2005","journal-title":"Nat. Prod. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jfca.2006.07.003","article-title":"Determination of antioxidant activity and antioxidant compounds in wild edible mushrooms","volume":"20","author":"Elmstats","year":"2007","journal-title":"J. Food Compos. Anal."},{"key":"ref_4","first-page":"353","article-title":"Biological activities of the lignicolous fungus Meripilus giganteus (Pers.:Pers.)","volume":"61","author":"Karaman","year":"2009","journal-title":"Karst. Arch. Biol. Sci."},{"key":"ref_5","first-page":"387","article-title":"Lignicolous fungi from northern Serbia as natural sources of antioxidants","volume":"4","author":"Karaman","year":"2009","journal-title":"Cent. Eur. J. Biol."},{"key":"ref_6","first-page":"39","article-title":"Evaluation of antioxidant and nitric oxide synthase activation properties of Armillaria mellea Quel","volume":"1","author":"Rai","year":"2009","journal-title":"e J. Biol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1615\/InterJMedicMush.v5.i2.40","article-title":"Edible and medicinal higher basidomycetes mushrooms as a source of natural antioxidants","volume":"5","author":"Badalyan","year":"2003","journal-title":"Int. J. Med. Mushr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.foodchem.2005.11.043","article-title":"Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: individual cap and stipe activity","volume":"100","author":"Ferreira","year":"2007","journal-title":"Food Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/BF00173319","article-title":"Effect of medium composition on 1-octen-3-ol formation in submerged cultures of Pleurotus pumonarius","volume":"40","author":"Belinky","year":"1994","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.lwt.2004.08.010","article-title":"Antioxidant properties of hot water extracts from Gonaderma tsugae Murrill","volume":"38","author":"Mau","year":"2008","journal-title":"LWT Food Sci. Technol."},{"key":"ref_11","unstructured":"Fan, A., and Alexeeff, G. Public Health Goal for Carbontetrachloride in Drinking Water. Available online:http:\/\/www.oehha.org\/water\/phg\/pdf\/carbtet.pdf\/."},{"key":"ref_12","unstructured":"Chang, S.-T., and Miles, P.G. (2004). Mushrooms Cultivation, Nutritional Value, Medicinal Effect, and Environmental Impact, CRC Press. [2nd]."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sabo, A., Stilinovic, N., Vukmirovic, S., Bukumiric, Z., Capo, I., and Jakovljevic, V. (2010). Pharmacodynamic Action of a Commercial Preparation of the Mushroom Coprinus comatus in Rats. Phytother. Res.","DOI":"10.1002\/ptr.3182"},{"key":"ref_14","first-page":"536","article-title":"The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas","volume":"50","author":"Szkudelski","year":"2001","journal-title":"Physiol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0009-2797(00)00149-6","article-title":"Cytochrome P4502E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes","volume":"125","author":"Zanger","year":"2000","journal-title":"Chem. Biol. Interact."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.nutres.2005.01.001","article-title":"Effects of Fomes fomentarius supplementation on antioxidant enzyme activities, blood glucose, and lipid profile in streptozotocin-induced diabetic rats","volume":"25","author":"Lee","year":"2005","journal-title":"Nutr. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1078\/0940-2993-00351","article-title":"Hepatic changes in the acute phase of streptozocin (SZ)-induced diabetes in mice","volume":"55","author":"Kume","year":"2004","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Vogel, G., and Vogel, W.H. (1997). Drug Discovery and Evaluation, Pharmacological assays, Springer verlag.","DOI":"10.1007\/978-3-662-03333-3"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hewitson, T.D., and Darby, I.A. (2009). Histology Protocols, Humana Press.","DOI":"10.1007\/978-1-60327-345-9"},{"key":"ref_20","unstructured":"Fleischer, S., and Parker, L. (1988). Methods in Enzymology, Academic Press."},{"key":"ref_21","first-page":"389","article-title":"Study of Metabolism Enzymes during the Development of Phaseolus vulgaris","volume":"166","author":"Simon","year":"1974","journal-title":"Plant Physiol. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"Spectrophotometric Method for Measuring of Breakdown of Hydrogen Peroxide by Catalase","volume":"195","author":"Beers","year":"1950","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0005-2744(76)90110-8","article-title":"Purification of Rat Lung Soluble Glutathione Peroxidase","volume":"445","author":"Chin","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bergmayer, U.H. (1970). Methoden Der Enzymatischen Analyse, Verlag Chemie.","DOI":"10.1515\/9783112719336"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-3565(25)31613-7","article-title":"Inhibition of Acetaminophen Induced Hepatotoxicity by Phenacetin and Its Alkoxy Analogs","volume":"209","author":"Mieyal","year":"1979","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Estimation of Total Protein in Tissue Homogenate","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/15\/7\/4564\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:02:46Z","timestamp":1760220166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/15\/7\/4564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,24]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7]]}},"alternative-id":["molecules15074564"],"URL":"https:\/\/doi.org\/10.3390\/molecules15074564","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,24]]}}}