{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:13:37Z","timestamp":1790673217587,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T00:00:00Z","timestamp":1282867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-\u03b1-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-\u03b2-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.<\/jats:p>","DOI":"10.3390\/molecules15095866","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T11:02:35Z","timestamp":1282906955000},"page":"5866-5877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits"],"prefix":"10.3390","volume":"15","author":[{"given":"Nikoletta G.","family":"Ntalli","sequence":"first","affiliation":[{"name":"Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Cottiglia","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Bueno","sequence":"additional","affiliation":[{"name":"Bueno, C.A. and Alch\u00e9, L.E. Laboratorio de Virolog\u00eda, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, 4to. Piso, Ciudad Universitaria, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Alch\u00e9","sequence":"additional","affiliation":[{"name":"Bueno, C.A. and Alch\u00e9, L.E. Laboratorio de Virolog\u00eda, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, 4to. Piso, Ciudad Universitaria, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Leonti","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Vargiu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Universit\u00e0 degli Studi di Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersilia","family":"Bifulco","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Universit\u00e0 degli Studi di Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urania","family":"Menkissoglu-Spiroudi","sequence":"additional","affiliation":[{"name":"Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-3767","authenticated-orcid":false,"given":"Pierluigi","family":"Caboni","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Universit\u00e0 degli Studi di Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.ento.51.110104.151146","article-title":"Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world","volume":"51","author":"Isman","year":"2006","journal-title":"Annu. 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