{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:19:55Z","timestamp":1773940795604,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T00:00:00Z","timestamp":1287100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Leaves and bark infusions Anacardium humile St. Hil. (Anacardiaceae), known as in Brazil as \u201ccajuzinho do cerrado\u201d, have been used in folk medicine as an alternative treatment for ulcers and gastritis. This study evaluated the gastroprotective activity of an ethyl acetate extract of the leaves of A. humile (AcF) and the mechanism involved in this gastroprotection. Pretreatment concentrations (50, 100, 200 mg.kg\u22121) were administered by gavage. Following a 60 min. period, all the rats were orally administered 1 mL of absolute ethanol. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated. Prostaglandin PGE2 concentration, gastric adherent mucous, and the participation of nitric oxide (NO) and sulfhydryl compounds in the gastroprotection process were also analyzed using the most effective tested dose (50 mg\u00b7kg\u22121). A histological study of the glandular stomach for the evaluation of the epithelial damage and mucus content was also performed. AcF significantly reduced the gastric damage produced by ethanol. This effect was statistically significant for the 50 mg\u00b7kg\u22121 group compared to control. Also, it significantly increased the PGE2 (by 10-fold) and mucous production, while pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) or N-ethylmaleimide (NEM) completely abolished the gastroprotection. AcF has a protective effect against ethanol, and this effect, might be due to the augmentation of the protective mechanisms of mucosa.<\/jats:p>","DOI":"10.3390\/molecules15107153","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T10:51:19Z","timestamp":1287139879000},"page":"7153-7166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats"],"prefix":"10.3390","volume":"15","author":[{"given":"Anderson","family":"Luiz-Ferreira","sequence":"first","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Alves de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edra","family":"Cola","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Barbastefano","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Beatriz Albino de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u00f4nia Maria","family":"Batista","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba - UFPB, Cx. Postal 5009, 58051-970, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis\u00e2ngela","family":"Farias-Silva","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Helena","family":"Pellizzon","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia, Instituto de Bioci\u00eancias, Universidade Estadual Paulista, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9lia Akiko","family":"Hiruma-Lima","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Instituto de Bioci\u00eancias, Universidade Estadual Paulista, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes Campaner","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Estadual Paulista, Araraquara, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3032-2556","authenticated-orcid":false,"given":"Wagner","family":"Vilegas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Estadual Paulista, Araraquara, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba Regina Monteiro Souza","family":"Brito","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia, Biologia Celular, Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2010,10,15]]},"reference":[{"key":"ref_1","first-page":"3198","article-title":"Gastric and duodenal antiulcer activity of alkaloids: A review","volume":"12","author":"Leite","year":"2008","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2174\/1566524013363483","article-title":"Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species, protection by melatonin","volume":"1","author":"Bandyopadhyay","year":"2001","journal-title":"Curr. 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