{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:47:02Z","timestamp":1790254022432,"version":"4.1.0"},"reference-count":18,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T00:00:00Z","timestamp":1295222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tithonia diversifolia is a medicinal plant from the Municipality of Suchiapa, Chiapas, Mexico, that according to local folk medicine is considered useful in the treatment of gastric ulcers. The aim of the present study was to investigate the gastroprotective activity of T. diversifolia by using an ethanol-induced gastric ulcer experimental model in male Wistar rats. The results showed that T. diversifolia had gastroprotective activity, and that the dichloromethane extract had the highest protective activity (close to 90% when using doses between 10 to 100 mg\/kg), and that further the compound tagitinin C isolated from this extract was the main active gastroprotective agent. Rats treated with tagitinin C suspended in Tween 80 at 1, 3, 10 and 30 mg\/kg showed 37.7, 70.1, 100, and 100% gastroprotection, respectively. The effect elicited by tagitinin C (30 mg\/kg) was not attenuated by pretreatment with either NG-nitro-L-arginine methyl ester (70 mg\/kg, i.p.), a nitric oxide (NO) synthase inhibitor, N-ethylmaleimide (10 mg\/kg, s.c.), a blocker of sulfhydryl groups, or indomethacin (10 mg\/kg, s.c.), a blocker of prostaglandin synthesis, which suggests that the gastroprotective mechanism of action of this sesquiterpene lactone does not involve NO, sulfhydryl groups or prostaglandins.<\/jats:p>","DOI":"10.3390\/molecules16010665","type":"journal-article","created":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T10:51:01Z","timestamp":1295261461000},"page":"665-674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Bioassay-Guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls"],"prefix":"10.3390","volume":"16","author":[{"given":"Mar\u00eda Elena","family":"S\u00e1nchez-Mendoza","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo 11340, M\u00e9xico D. F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelfo","family":"Reyes-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ej\u00e9rcito de Oriente, M\u00e9xico D.F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Cruz Antonio","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ej\u00e9rcito de Oriente, M\u00e9xico D.F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mart\u00ednez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo 11340, M\u00e9xico D. F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rodr\u00edguez-Silverio","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo 11340, M\u00e9xico D. F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo 11340, M\u00e9xico D. F., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3109\/13880200903453131","article-title":"Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)","volume":"48","author":"Bucciarelli","year":"2010","journal-title":"Pharm. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bmcl.2009.11.024","article-title":"Gastroprotective flavonoid constituents from Oroxylum indicum Vent","volume":"20","author":"Babu","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jep.2010.05.014","article-title":"Antiulcer effects of Achyrocline satureoides (Lam.) 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