{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:42:52Z","timestamp":1773675772394,"version":"3.50.1"},"reference-count":10,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:00:00Z","timestamp":1297382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.<\/jats:p>","DOI":"10.3390\/molecules16021508","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T11:07:40Z","timestamp":1297422460000},"page":"1508-1518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Polycationic Glycosides"],"prefix":"10.3390","volume":"16","author":[{"given":"Robert","family":"Engel","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishrat","family":"Ghani","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Klaritch-Vrana","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, 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of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Capodiferro","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ambinder","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Cere","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaimeLee","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa-Marie","family":"Nisbett","sequence":"additional","affiliation":[{"name":"Department of Biology, Long Island University, C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Testani","sequence":"additional","affiliation":[{"name":"Department of Biology, Long Island University, C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Melkonian","sequence":"additional","affiliation":[{"name":"Department of Biology, Long Island University, C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/S0008-6215(02)00316-6","article-title":"Preparation and investigation of carbohydrate-based surfaces","volume":"337","author":"Abel","year":"2002","journal-title":"Carbohydr. Res."},{"key":"ref_2","first-page":"1","article-title":"Polycations. 14. Preparation and investigation of protein-based antibacterial surfaces","volume":"3","author":"Abel","year":"2004","journal-title":"J. Textile Apparel Technol. Manage."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1570180043485752","article-title":"Polycations. 15. Polyammonium surfaces - a new approach to antifungal activity","volume":"1","author":"Cohen","year":"2004","journal-title":"Lett. Drug Des. Disc."},{"key":"ref_4","unstructured":"Engel, R., Cohen, J.I., and Melkonian, K. (2007). Antimoicrobial surfaces. (7,285,286), U.S. Patent."},{"key":"ref_5","unstructured":"Engel, R., Cohen, J.I., and Melkonian, K. (2007). Antimoicrobial surfaces. (7,241,453), U.S. Patent."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.chemphyslip.2008.12.003","article-title":"Polycations. 18. The synthesis of polycationic lipid materials based on the diamine 1,4-diazabicyclo[2.2.2]octane","volume":"158","author":"Engel","year":"2009","journal-title":"Chem. Phys. Lipids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/1098-1071(2000)11:7<546::AID-HC14>3.0.CO;2-R","article-title":"Polycations. IX. Polyammonium derivatives of cyclodextrins - synthesis and binding to organic oxyanions","volume":"11","author":"Cohen","year":"2000","journal-title":"Heteroat. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Fabian, J., October, T., Cherestes, A., and Engel, R. (1997). Polycations: Syntheses of polyammonium strings as antibacterial agents. Synlett, 1007\u20131009.","DOI":"10.1055\/s-1997-953"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/abbi.1999.1108","article-title":"Polycations. 5. Inducement of \u0470-DNA circular dichroism signals for duplex deoxyribonucleotide homopolymers by polycationic strings","volume":"364","author":"Strekas","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8617","DOI":"10.1016\/S0040-4039(98)01953-4","article-title":"Polycations. 4. Synthesis and antihydrophobic effect of polycationic strings","volume":"39","author":"Cohen","year":"1998","journal-title":"Tetrahedron Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/16\/2\/1508\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:55:12Z","timestamp":1760219712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/16\/2\/1508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,11]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2]]}},"alternative-id":["molecules16021508"],"URL":"https:\/\/doi.org\/10.3390\/molecules16021508","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,11]]}}}