{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:06:53Z","timestamp":1780668413318,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity.<\/jats:p>","DOI":"10.3390\/molecules16021825","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T11:18:06Z","timestamp":1298373486000},"page":"1825-1833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives"],"prefix":"10.3390","volume":"16","author":[{"given":"Juliana A.","family":"Peixoto","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. Dr. Armando Salles de Oliveira 201 - Parque Universit\u00e1rio, CEP 14404-600, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Luis","family":"Andrade e Silva","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. Dr. Armando Salles de Oliveira 201 - Parque Universit\u00e1rio, CEP 14404-600, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio E. M.","family":"Crotti","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. Dr. Armando Salles de Oliveira 201 - Parque Universit\u00e1rio, CEP 14404-600, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Cassio Sola Veneziani","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. Dr. Armando Salles de Oliveira 201 - Parque Universit\u00e1rio, CEP 14404-600, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria M. M.","family":"Gimenez","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Claretiano, Rua Dom Bosco 466, CEP 14300-000, Batatais, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana H.","family":"Janu\u00e1rio","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. Dr. Armando Salles de Oliveira 201 - Parque Universit\u00e1rio, CEP 14404-600, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Groppo","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. do Caf\u00e9 s\/n CEP 14040-901 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizandra G.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. 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Dr. Armando Salles de Oliveira 201 - Parque Universit\u00e1rio, CEP 14404-600, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, CEP 14040-903, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar A.","family":"Da Silva Filho","sequence":"additional","affiliation":[{"name":"Departamento Farmac\u00eautico, Universidade Federal de Juiz de Fora, Rua Jos\u00e9 Louren\u00e7o Kelmer s\/n, Campus Universit\u00e1rio, CEP 36036-900, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson R.","family":"Cunha","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas da Universidade de Franca, Av. 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