{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:37:58Z","timestamp":1791344278585,"version":"4.3.1"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with \u03b2-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.<\/jats:p>","DOI":"10.3390\/molecules16021878","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T11:18:06Z","timestamp":1298373486000},"page":"1878-1887","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues"],"prefix":"10.3390","volume":"16","author":[{"given":"Huanan","family":"Hu","sequence":"first","affiliation":[{"name":"College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfu","family":"Song","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The Cholinergic Hypothesis of Geriatric Memory Dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0140-6736(95)90526-X","article-title":"Tacrine","volume":"345","author":"Davis","year":"1995","journal-title":"Lancet"},{"key":"ref_3","unstructured":"Brioni, J.D., and Decker, M.W. 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