{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:15:30Z","timestamp":1779351330458,"version":"3.51.4"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>6-[(4-Methoxy\/4,9-dimethoxy)-7-methylfurochromen-5-ylideneamino]-2-thioxo-2,3-dihydropyrimidin-4-ones 1a,b were prepared by reaction of 6-amino-2-thiouracil with visnagen or khellin, respectively. Reaction of 1a,b with methyl iodide afforded furochromenylideneaminomethylsulfanylpyrimidin-4-ones 2a,b. Compounds 2a,b were reacted with secondary aliphatic amines to give the corresponding furochromen-ylideneamino-2-substituted pyrimidin-4-ones 3a\u2013d. Reaction of 3a\u2013d with phosphorus oxychloride yielded 6-chlorofurochromenylidenepyrimidinamines 4a\u2013d, which were reacted with secondary amines to afford furochromenylideneamino-2,6-disubstituted pyrimidin-4-ones 5a\u2013d. In addition, reaction of 5a\u2013d with 3-chloropentane-2,4-dione gave 3-chloro-furochromenylpyrimidopyrimidines 6a\u2013d. The latter were reacted with piperazine and morpholine to give 1-(furochromenyl)-pyrimidopyrimidine-3,6,8-triylpiperazines or -3,6,8-triylmorpholines 7a\u2013d. The chemical structures of the newly synthesized compound ware characterized by IR, 1H-NMR, 13C-NMR and mass spectral analysis. These compounds were also screened for their analgesic and anti-inflammatory activities. Some of them, particularly 3\u20137, exhibited promising activities.<\/jats:p>","DOI":"10.3390\/molecules16031956","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T10:46:03Z","timestamp":1298630763000},"page":"1956-1972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Synthesis of New Visnagen and Khellin Furochromone Pyrimidine Derivatives and Their Anti-Inflammatory and Analgesic Activity"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-2806","authenticated-orcid":false,"given":"Ameen Ali","family":"Abu-Hashem","sequence":"first","affiliation":[{"name":"Departments of Photochemistry, National Research Center, 12622 Dokki, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed M.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/hrt.12.1.54","article-title":"Khellin in the treatment of angina of effort","volume":"12","author":"Dewar","year":"1950","journal-title":"Br. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.phymed.2009.10.011","article-title":"An aqueous extract of Ammi visnaga fruits and its constituents Khellin and Visnagen prevent cell damage caused by oxalate in renal epithelial cells","volume":"17","author":"Vanachayangkul","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.jcrysgro.2009.02.027","article-title":"Effect of supersaturation ratio and Khella extract on nucleation and morphology of kidney stones","volume":"311","author":"Daosukho","year":"2009","journal-title":"J. Crystal. 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