{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:30:15Z","timestamp":1767961815851,"version":"3.49.0"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:00:00Z","timestamp":1302739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 \u00b1 0.70%, 90.93 \u00b1 1.41% and 86.31 \u00b1 8.46%, respectively, at a concentration of 10 \u03bcM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.<\/jats:p>","DOI":"10.3390\/molecules16043146","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T11:14:55Z","timestamp":1302779695000},"page":"3146-3151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz"],"prefix":"10.3390","volume":"16","author":[{"given":"Hai","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Rd., Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0960-0760(01)00127-3","article-title":"Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents","volume":"79","author":"Brueggemeier","year":"2001","journal-title":"J. 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