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Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/anie.200462873","article-title":"Amino Acids\u2013Valuable Organocatalysts in carbohydrate Synthesis","volume":"44","author":"Kazmaier","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.1016\/j.tet.2007.06.024","article-title":"Asymmetric organocatalysis","volume":"63","author":"Pellissier","year":"2007","journal-title":"Tetrahedron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.drudis.2006.11.004","article-title":"Enantioselective organocatalysis","volume":"12","author":"Gaunt","year":"2007","journal-title":"Drug Discov. Today"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1002\/anie.200704684","article-title":"Asymmetric Organocatalysis: From Infancy to Adolescence","volume":"47","author":"Dondoni","year":"2008","journal-title":"Angew. Chem. Int. 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Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/cssc.200900144","article-title":"Organocatalytic, asymmetric aldol reactions with a sustainable catalyst in a green solvent","volume":"2","author":"North","year":"2009","journal-title":"ChemSusChem"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.tetasy.2010.03.051","article-title":"Cyclic carbonates as sustainable solvents for proline-catalysed aldol reactions","volume":"21","author":"Clegg","year":"2010","journal-title":"Tetrahedron: Asymmetry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1021\/ol1007313","article-title":"A Chiral Solvent Effect in Asymmetric Organocatalysis","volume":"12","author":"North","year":"2010","journal-title":"Org. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/1521-3773(20020517)41:10<1790::AID-ANIE1790>3.0.CO;2-Y","article-title":"Direct Organo-Catalytic Asymmetric \u03b1-Amination of Aldehydes\u2013A Simple Approach to Optically Active \u03b1-Amino Aldehydes, \u03b1-Amino Alcohols, and \u03b1-Amino Acids","volume":"41","author":"Juhl","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11770","DOI":"10.1021\/ja046258x","article-title":"In Situ Catalyst Improvement in the Proline-Mediated \u03b1-Amination of Aldehydes","volume":"126","author":"Iwamura","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"16312","DOI":"10.1021\/ja0444177","article-title":"Probing the Active Catalyst in Product-Accelerated Proline-Mediated Reactions","volume":"126","author":"Iwamura","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Umbreen, S., Brockhaus, M., Ehrenberg, H., and Schmidt, B. (2006). Norstatines from Aldehydes by Sequential Organocatalytic \u03b1-Amination and Passerini Reaction. Eur. J. Org. Chem., 4585\u20134595.","DOI":"10.1002\/ejoc.200600502"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Baumann, T., Vogt, H., and Br\u00e4se, S. (2007). The Proline-Catalyzed Asymmetric Amination of Branched Aldehydes. Eur. J. Org. Chem., 266\u2013282.","DOI":"10.1002\/ejoc.200600654"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1021\/ol800574v","article-title":"First Asymmetric Total Syntheses of Cernuane-Type Lycopodium Alkaloids, Cernuine, and Cermizine D","volume":"10","author":"Nishikawa","year":"2008","journal-title":"Org. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, Y., Peng, F., Zhang, H., and Shao, Z. (2009). Organocatalytic Synthesis of Terminal Propargylamine Derivatives by Tandem Amination\u2013Alkynylation. Synlett, 3287\u20133290.","DOI":"10.1055\/s-0029-1218354"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1021\/ja102718x","article-title":"Unusual Reversal of Enantioselectivity in the Proline-Mediated \u03b1-Amination of Aldehydes Induced by Tertiary Amine Additives","volume":"132","author":"Blackmond","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1021\/ja0261325","article-title":"Direct Catalytic Asymmetric \u03b1-Amination of Aldehydes","volume":"124","author":"List","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1021\/ja026412k","article-title":"Direct L-Proline-Catalyzed Asymmetric \u03b1-Amination of Ketones","volume":"124","author":"Kumaragurubaran","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1021\/ol0512942","article-title":"Organocatalytic Enantioselective Synthesis of Metabotropic Glutamate Receptor Ligands","volume":"7","author":"Suri","year":"2005","journal-title":"Org. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1021\/ol063012j","article-title":"Organocatalytic Sequential \u03b1-Amination-Horner-Wadsworth-Emmons Olefination of Aldehydes: Enantioselective Synthesis of \u03b3-Amino-\u03b1,\u03b2-Unsaturated Esters","volume":"9","author":"Kotkar","year":"2007","journal-title":"Org. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Baumann, T., B\u00e4chle, M., Hartmann, C., and Br\u00e4se, S. (2008). Thermal Effects in the Organocatalytic Asymmetric \u03b1-Amination of Disubstituted Aldehydes with Azodicarboxylates: A High-Temperature Organocatalysis. Eur. J. Org. Chem., 2207\u20132212.","DOI":"10.1002\/ejoc.200701167"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1039\/b916372g","article-title":"Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin","volume":"7","author":"Hartmann","year":"2009","journal-title":"Org. Biomol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ait-Youcef, R., Sbargoud, K., Moreau, X., and Greck, C. (2009). Asymmetric \u03b1-Amination of Chiral Protected \u03b2-Hydroxyaldehydes Catalyzed by Proline. Synlett, 3007\u20133010.","DOI":"10.1055\/s-0029-1218001"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tetlet.2008.11.054","article-title":"Efficient syntheses of enantioenriched (R)-pipecolic acid and (R)-proline via electrophilic organocatalytic amination","volume":"50","author":"Kalch","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.tetasy.2010.04.026","article-title":"Asymmetric synthesis of deuterated and fluorinated aromatic \u03b1,\u03b1-disubstituted amino acid derivatives","volume":"21","author":"Hartmann","year":"2010","journal-title":"Tetrahedron: Asymmetry"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kotrusz, P., Alemayehu, S., Toma, \u0160., Schmalz, H.-G., and Adler, A. (2005). Enantioselective Organocatalysis in Ionic Liquids: Addition of Aliphatic Aldehydes and Ketones to Diethyl Azodicarboxylate. Eur. J. Org. Chem., 4904\u20134911.","DOI":"10.1002\/ejoc.200500481"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Liu, P.-M., Chang, C., Reddy, R.J., Ting, Y.-F., Kuan, H.-H., and Chen, K. (2010). Remarkable Reaction Rate and Excellent Enantioselective Direct \u03b1-Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinylcamphor-Derived Organocatalysts. Eur. J. Org. Chem., 42\u201346.","DOI":"10.1002\/ejoc.200901151"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1016\/j.tetlet.2010.06.017","article-title":"Synthesis and use of a stable aminal derived from TsDPEN in asymmetric organocatalysis","volume":"51","author":"Gosiewska","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lacoste, E., Vaique, E., Berlande, M., Pianet, I., Vincent, J.-M., and Landais, Y. (2007). Benzimidazole-pyrrolidine\/H+ (BIP\/H+), a Highly Reactive Organocatalyst for Asymmetric Processes. Eur. J. Org. Chem., 167\u2013177.","DOI":"10.1002\/ejoc.200600664"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.tetlet.2005.12.028","article-title":"Amino acid-catalyzed asymmetric \u03b1-amination of carbonyls","volume":"47","author":"Thomassigny","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1016\/j.tetlet.2008.09.054","article-title":"A short enantioselective synthesis of (\u2013)-bestatin via L-proline-catalyzed \u03b1-amination of an aldehyde","volume":"49","author":"George","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/157017809788681293","article-title":"Asymmetric \u03b1-Amination of Aldehydes and Ketones Catalyzed by tert-Butoxy-L-Proline","volume":"6","author":"Kalch","year":"2009","journal-title":"Lett. Org. 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