{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:31:13Z","timestamp":1790141473075,"version":"4.0.1"},"reference-count":14,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a\u2013n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a\u2013c with suitably substituted secondary amines. The starting 2-thioxo- imidazolidin-4-ones 2a,2b were prepared by condensation of thiohydantoin and benzo[b]-thiophene-3-carbaldehyde or benzofuran-3-carbaldehyde under microwave irracdiation (MW) conditions. 2-Methylthio derivatives 3a\u2013c were prepared by treatment of 2a\u2013b with methyl iodide in the presence of aqueous sodium hydroxide.<\/jats:p>","DOI":"10.3390\/molecules16075527","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T14:09:59Z","timestamp":1309356599000},"page":"5527-5537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles"],"prefix":"10.3390","volume":"16","author":[{"given":"Sukanta","family":"Kamila","sequence":"first","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haribabu","family":"Ankati","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Biehl","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0079-6468(08)70120-6","article-title":"Anticonvulsant drugs","volume":"3","author":"Spinks","year":"1963","journal-title":"Prog. Med. Chem."},{"key":"ref_2","first-page":"561","article-title":"Synthesis of certain 5-substituted 2-thiohydantoin derivatives as potential cytotoxic and antiviral agents","volume":"136","author":"Khodair","year":"1997","journal-title":"Boll Chim Farm"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00001813-199611000-00009","article-title":"5-Substituted-2-thiohydant-oin analogs as a novel class of antitumor agent","volume":"7","author":"Khodair","year":"1996","journal-title":"Anti-Cancer Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/jm00027a009","article-title":"S-Glucosylated hydantoins as new antiviral agents","volume":"37","author":"Khodair","year":"1994","journal-title":"J. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1359-6101(99)00005-2","article-title":"The MCP\/eotaxin subfamily of CC chemokines","volume":"10","author":"Opdenakker","year":"1999","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0014-2999(03)02179-4","article-title":"The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock","volume":"29","author":"Collin","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"139S","DOI":"10.1097\/01.ALC.0000134412.38510.F7","article-title":"Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-alpha","volume":"28","author":"Ohata","year":"2004","journal-title":"Alcohol. Clin. Exp. 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