{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:24:32Z","timestamp":1771874672006,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T00:00:00Z","timestamp":1309737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of S-glycosyl and S-alkyl derivatives of 4-amino-3-mercapto-6-(2-(2-thienyl)vinyl)-1,2,4-triazin-5(4H)-one (1) were synthesized using different halo compounds such as preacetylated sugar bromide, 4-bromobutylacetate, 2-acetoxyethoxy-methyl bromide, 3-chloropropanol, 1,3-dichloro-2-propanol, epichlorohydrin, allyl bromide, propargyl bromide, phthalic and succinic acids in POCl3. The structures of the synthesized compounds have been deduced from their elemental analysis and spectral (IR, 1H-NMR, and 13C-NMR) data. Some of the synthesized compounds were screened as anticancer agents. Significant anticancer activities were observed in vitro for some members of the series, and compounds 4-Amino-3-(3-hydroxypropylthio)-6-(2-(2-thienyl)vinyl)-1,2,4-triazin-5(4H)-one (12) and 3-(4-Oxo-3-(2-(2-thienyl)vinyl)-4H-[1,3,4]thiadiazolo-[2,3-c][1,2,4]tr-iazin-7-yl)propanoic acid (18) are active cytotoxic agents against different cancer cell lines.<\/jats:p>","DOI":"10.3390\/molecules16075682","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T15:06:10Z","timestamp":1309791970000},"page":"5682-5700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis and Anticancer Activity of Some New S-Glycosyl and S-Alkyl 1,2,4-Triazinone Derivatives"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-7477","authenticated-orcid":false,"given":"Hosam A.","family":"Saad","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Taif University, Taif, 21974, Kingdom of Saudi Arabia"},{"name":"Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed H.","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,7,4]]},"reference":[{"key":"ref_1","unstructured":"Robins, M.J., Walker, R.T., De Clercq, E., and Eckstein, F. 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