{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:24:03Z","timestamp":1770971043952,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The synthesis and structure of palladium complexes of trisubstituted PTA derivatives, PTAR3, are described. Water-soluble phosphine ligands 1,3,5-triaza-7-phosphaadmantane (PTA), tris(aminomethyl)phosphine trihydrobromide, tri(aminomethyl) phosphine, 3,7-dimethyl-1,5,7-triaza-3-phosphabicyclo[3,3,1]nonane (RO-PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), lithium 1,3,5-triaza-7-phosphaadamantane-6-carboxylate (PTA-CO2Li), 2,4,6-triphenyl-1,3,5-triaza-7-phosphatricyclo [3.3.1.1]decane, and 2,4,6-triphenyl-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane were used as ligands for palladium catalyzed Suzuki reactions in aqueous media. RO-PTA in combination with palladium acetate or palladium chloride was the most active catalyst for Suzuki cross coupling of aryl bromides and phenylboronic acid at 80 \u00b0C in 1:1 water:acetonitrile. The activity of Pd(II) complexes of RO-PTA is comparable to PPh2(m-C6H4SO3Na) (TPPMS) and P(m-C6H4SO3Na)3 (TPPTS) and less active than tri(4,6-dimethyl-3-sulfonatophenyl)phosphine trisodium salt (TXPTS). Activated, deactivated, and sterically hindered aryl bromides were examined, with yields ranging from 50% to 90% in 6 h with 5% palladium precatalyst loading. X-ray crystal structures of (RO-PTA)PdCl2, (PTAR3)2PdCl2 (R = Ph, p-tert-butylC6H5), and PTAR3 (R = p-tert-butylC6H5) are reported.<\/jats:p>","DOI":"10.3390\/molecules16086215","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T12:35:29Z","timestamp":1311597329000},"page":"6215-6231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Suzuki Reaction in Aqueous Media Promoted by P, N Ligands"],"prefix":"10.3390","volume":"16","author":[{"given":"Jason A.","family":"Weeden","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Nevada, Reno NV 89557, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongcai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Nevada, Reno NV 89557, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn D.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Nevada, Reno NV 89557, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip W.","family":"Gingrich","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Nevada, Reno NV 89557, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Nevada, Reno NV 89557, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1021\/cr100327p","article-title":"Advances in transition metal (Pd, Ni, Fe)-catalyzed cross-coupling reactions using alkyl-organometallics as reaction partners","volume":"111","author":"Jana","year":"2011","journal-title":"Chem. 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