{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:56:13Z","timestamp":1773860173296,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl4)-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg\/kg of bw) or bifendate (100 mg\/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl4-induced hepatotoxicity. The 20% CCl4\/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl4-treated group were administered with CCl4 twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl4-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects.<\/jats:p>","DOI":"10.3390\/molecules16108684","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T05:04:21Z","timestamp":1318914261000},"page":"8684-8693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl4-Induced Hepatic Damage"],"prefix":"10.3390","volume":"16","author":[{"given":"Ruidong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiren","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoshan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00795-006-0313-z","article-title":"Studies on oxidative stress in liver diseases: Important future trends in liver research","volume":"39","author":"Tanikawa","year":"2006","journal-title":"Med. 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