{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:07:49Z","timestamp":1785928069423,"version":"3.56.0"},"reference-count":60,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new approach for the synthesis of indatraline was developed using as the key step an iodine(III)-mediated ring contraction of a 1,2-dihydronaphthalene derivative. Behavioral tests were conducted to evaluate the effect of indatraline and of its precursor indanamide on the motor activity of Wistar rats. Specific indexes for ambulation, raising and stereotypy were computed one, two and three hours after i.p. drug administration. Indatraline effects on motor activity lasted for at least three hours. On the other hand, no significant differences in motor activity were observed using indanamide. The results suggest that indatraline has a long lasting effect on motor activity and add evidence in favor of the potential use of that compound as a substitute in cocaine addiction.<\/jats:p>","DOI":"10.3390\/molecules16119421","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T11:10:58Z","timestamp":1320923458000},"page":"9421-9438","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats"],"prefix":"10.3390","volume":"16","author":[{"given":"M\u00e1rcia","family":"Kameyama","sequence":"first","affiliation":[{"name":"Department of Experimental Psychology, Institute of Psychology, University of S\u00e3o Paulo, USP, Av. Prof. Mello de Moraes, 1721, Cidade Universit\u00e1ria, S\u00e3o Paulo SP CEP 05508-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda A.","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, CP 26077, S\u00e3o Paulo-SP, 05513-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Garcia-Mijares","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Institute of Psychology, University of S\u00e3o Paulo, USP, Av. Prof. Mello de Moraes, 1721, Cidade Universit\u00e1ria, S\u00e3o Paulo SP CEP 05508-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"F. Silva, Jr.","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, CP 26077, S\u00e3o Paulo-SP, 05513-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Institute of Psychology, University of S\u00e3o Paulo, USP, Av. Prof. Mello de Moraes, 1721, Cidade Universit\u00e1ria, S\u00e3o Paulo SP CEP 05508-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/j.1471-4159.1985.tb08803.x","article-title":"Neurochemical profile of Lu-19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin","volume":"44","author":"Hyttel","year":"1985","journal-title":"J. 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