{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:00Z","timestamp":1787029020664,"version":"build-2736575974"},"reference-count":21,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T00:00:00Z","timestamp":1327276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg\/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p &lt; 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p &lt; 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.<\/jats:p>","DOI":"10.3390\/molecules17011113","type":"journal-article","created":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T16:19:49Z","timestamp":1327335589000},"page":"1113-1123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities"],"prefix":"10.3390","volume":"17","author":[{"given":"Cristiane B.","family":"De Oliveira","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil"},{"name":"Laborat\u00f3rio de Biof\u00edsica Celular e Inflama\u00e7\u00e3o, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucimara N.","family":"Comunello","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adroaldo","family":"Lunardelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica Celular e Inflama\u00e7\u00e3o, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson H.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica Celular e Inflama\u00e7\u00e3o, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa G. S.","family":"Pires","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica Celular e Inflama\u00e7\u00e3o, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Lucas","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica Celular e Inflama\u00e7\u00e3o, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanusa","family":"Manfredini","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil"},{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Servi\u00e7o de Gen\u00e9tica M\u00e9dica, UFRGS, Porto Alegre, RS 93050-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Regla","family":"Vargas","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil"},{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Servi\u00e7o de Gen\u00e9tica M\u00e9dica, UFRGS, Porto Alegre, RS 93050-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone C. B.","family":"Gnoatto","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarbas R.","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica Celular e Inflama\u00e7\u00e3o, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Gosmann","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,1,23]]},"reference":[{"key":"ref_1","first-page":"76","article-title":"Baccharis (Compositae): A review update","volume":"vii","author":"Abad","year":"2007","journal-title":"ARKIVOC"},{"key":"ref_2","unstructured":"(2010). 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