{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:30:02Z","timestamp":1784676602054,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T00:00:00Z","timestamp":1328659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often found in pesticides, in substrates for radical chemistry and in synthetic intermediates towards thioureas and amidines. We now report the multicomponent reaction (MCR) of in situ-generated 1-azadienes with carbon disulfide. With this reaction, a one-step protocol towards the potentially interesting 3,6-dihydro-2H-1,3-thiazine-2-thiones was established and a small library was synthesized.<\/jats:p>","DOI":"10.3390\/molecules17021675","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T10:59:02Z","timestamp":1328698742000},"page":"1675-1685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Multicomponent Synthesis of 3,6-Dihydro-2H-1,3-thiazine-2-thiones"],"prefix":"10.3390","volume":"17","author":[{"given":"Art","family":"Kruithof","sequence":"first","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten L.","family":"Ploeger","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elwin","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Helliwell","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Manchester, Brunswick Street, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J. J. de","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco","family":"Ruijter","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano V. A.","family":"Orru","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University, De Boelelaan 1083, 1081HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1002\/anie.201006515","article-title":"Multicomponent reaction design in the quest for molecular complexity and diversity","volume":"50","author":"Ruijter","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1021\/jo701973d","article-title":"A multicomponent synthesis of triazinane diones","volume":"73","author":"Groenendaal","year":"2008","journal-title":"J. Org. 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