{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:40:58Z","timestamp":1791484858225,"version":"4.3.4"},"reference-count":25,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The aim of this study was to identify an anti-inflammatory compound from D. viscosa leaves. The structure of this bioactive substance was elucidated by IR and NMR studies, which indicated that this natural product corresponds to hautriwaic acid (HA). This diterpene exhibited good anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models by applications at doses of 0.25, 0.5 and 1.0 mg\/ear (60.2, 70.2 and 87.1% inhibition, respectively); additionally Dodonaea viscosa dichloro-methane extract (DvDE) displays a 97.8% anti-inflammatory effect at 3 mg\/kg. Multiple applications of DvDE at doses of 100 mg\/kg on TPA mice ear edema inhibited the edema-associated inflammation by 71.8%, while HA at doses of 15 mg\/kg, reduced edema to 64% and indomethacin 40%.<\/jats:p>","DOI":"10.3390\/molecules17044292","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T11:09:50Z","timestamp":1334056190000},"page":"4292-4299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Anti-inflammatory Activity of Hautriwaic Acid Isolated from Dodonaea viscosa Leaves"],"prefix":"10.3390","volume":"17","author":[{"given":"David Osvaldo","family":"Salinas-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Biodiversity and Conservation Research Center. (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Herrera-Ruiz","sequence":"additional","affiliation":[{"name":"Biomedical Research Center of the South (IMSS), Argentina 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salud","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Biological Systems, (UAM-Xochimilco), Calzada del Hueso 1100, Col. Villa Quietud, M\u00e9xico D.F. 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Enrique","family":"Jim\u00e9nez-Ferrer","sequence":"additional","affiliation":[{"name":"Biomedical Research Center of the South (IMSS), Argentina 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Biomedical Research Center of the South (IMSS), Argentina 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"ref_1","unstructured":"Borda, I.T., and Koff, R.S. (1992). NSAID. A Profile of Adverse Effects, Hanley and Belfus, Inc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM199102283240903","article-title":"High-dose intramuscular triamcinolone in severe, chronic, life-threatening asthma","volume":"324","author":"Ogirala","year":"1991","journal-title":"N. Engl. J. 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