{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:12:01Z","timestamp":1791252721875,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A three step synthesis of various thiobarbiturate derivatives 17\u201324 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1\u20138 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.<\/jats:p>","DOI":"10.3390\/molecules17044313","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T11:09:50Z","timestamp":1334056190000},"page":"4313-4325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate"],"prefix":"10.3390","volume":"17","author":[{"given":"Ahlem","family":"Bouhlel","sequence":"first","affiliation":[{"name":"Laboratoire de Pharmaco-Chimie Radicalaire, Facult\u00e9 de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Curti","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmaco-Chimie Radicalaire, Facult\u00e9 de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Vanelle","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmaco-Chimie Radicalaire, Facult\u00e9 de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1021\/cr950026m","article-title":"Manganese(III)-based oxidative free-radical cyclizations","volume":"96","author":"Snider","year":"1996","journal-title":"Chem. 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