{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:09:02Z","timestamp":1783487342295,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.<\/jats:p>","DOI":"10.3390\/molecules17044533","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T11:07:38Z","timestamp":1334574458000},"page":"4533-4544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3"],"prefix":"10.3390","volume":"17","author":[{"given":"Han","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China"},{"name":"College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/cber.19050380275","article-title":"Notizen \u00fcber Brom-dihydrouracil","volume":"38","author":"Gabriel","year":"1905","journal-title":"Chem. 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