{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T08:44:45Z","timestamp":1774082685302,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Different parts of four edible medicinal plants (Casearia capitellata, Baccaurea motleyana, Phyllanthus pulcher and Strobilanthus crispus), indigenous to Malaysia, were extracted in different solvents, sequentially. The obtained 28 extracts were evaluated for their in vitro anticancer properties, using the MTS assay, on four human cancer cell lines: colon (HT-29), breast (MCF-7), prostate (DU-145) and lung (H460) cancers. The best anticancer activity was observed for the ethyl acetate (EA) extract of Casearia capitellata leaves on MCF-7 cell lines with IC50 2.0 \u03bcg\/mL and its methanolic (MeOH) extract showed an outstanding activity against lung cancer cell lines. Dichloromethane (DCM) extract of Phyllanthus pulcher aerial parts showed the highest anticancer activity against DU-145 cell lines, while significant activity was exhibited by DCM extract of Phyllanthus pulcher roots on colon cancer cell lines with IC50 value of 8.1 \u03bcg\/mL. Total phenolic content (TPC) ranged over 1\u201340 mg gallic acid equivalents (GAE)\/g. For all the samples, highest yields of phenolics were obtained for MeOH extracts. Among all the extracts analyzed, the MeOH extracts of Strobilanthus crispus leaves exhibited the highest TPC than other samples (p &lt; 0.05). This study shows that the nature of phenol determines its anticaner activity and not the number of phenols present.<\/jats:p>","DOI":"10.3390\/molecules17055745","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T11:11:27Z","timestamp":1336993887000},"page":"5745-5756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anticancer Properties and Phenolic Contents of Sequentially Prepared Extracts from Different Parts of Selected Medicinal Plants Indigenous to Malaysia"],"prefix":"10.3390","volume":"17","author":[{"given":"Maznah","family":"Ismail","sequence":"first","affiliation":[{"name":"Laboratory of Molecular BioMedicine, Insitute of Bioscience, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia"},{"name":"Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gururaj","family":"Bagalkotkar","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular BioMedicine, Insitute of Bioscience, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular BioMedicine, Insitute of Bioscience, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia"},{"name":"Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadiza Altine","family":"Adamu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular BioMedicine, Insitute of Bioscience, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.lfs.2005.09.012","article-title":"Drug discovery from medicinal plants","volume":"78","author":"Balunas","year":"2005","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/138945006776054915","article-title":"The role of pharmacognosy in modern medicine and pharmacy","volume":"7","author":"Jones","year":"2006","journal-title":"Curr. 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