{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:58:52Z","timestamp":1778741932275,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties.<\/jats:p>","DOI":"10.3390\/molecules17066754","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T16:49:53Z","timestamp":1338828593000},"page":"6754-6768","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis"],"prefix":"10.3390","volume":"17","author":[{"given":"Virginia D.","family":"Kappel","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle F.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa H.","family":"Cazarolli","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul, Campus Universit\u00e1rio Laranjeiras do Sul, Bairro Vila Alberti, CEP 85303-775, Laranjeiras do Sul, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha M.","family":"Guesser","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos H. Blum","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Catarina, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloir P.","family":"Schenkel","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Catarina, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio H.","family":"Reginatto","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Catarina, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima R. M. B.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,6,4]]},"reference":[{"key":"ref_1","unstructured":"American Diabetes Association (2011). Diagnosis and Classification of Diabetes Mellitus, Diabetes Care."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00228-011-1038-z","article-title":"Prevention and current onset delay approaches of type 2 diabetes mellitus (T2DM)","volume":"67","author":"Souto","year":"2011","journal-title":"Eur. J. Clin. 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