{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:41:18Z","timestamp":1772307678228,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:00:00Z","timestamp":1343260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hyptis suaveolens is a medicinal plant that is, according to traditional medicine, considered useful in the treatment of gastric ulcers. Although its gastroprotective activity was reported, the active compounds have not been identified. Therefore, the aim of the present study was to identify at least one active compound potentially responsible for the gastroprotective activity of H. suaveolens by using a bioassay guided study with an ethanol-induced gastric ulcer experimental model in rats. The results show that the hexane extract had protective activity (close to 70% when using doses between 10 and 100 mg\/kg), and that the compound suaveolol, isolated from this extract, was one of the active gastroprotective agents. This is the first report about the gastroprotective activity of suaveolol. Rats treated with this compound at 3, 10, 30 and 100 mg\/kg showed 12.6, 21.3, 39.6 and 70.2% gastroprotection respectively. The effect elicited by suaveolol (at 100 mg\/kg) was attenuated by pretreatment with either NG-nitro-L-arginine methyl ester (70 mg\/kg, i.p.), a nitric oxide (NO) synthase inhibitor, indomethacin (10 mg\/kg, s.c.), a blocker of prostaglandin synthesis, or N-ethylmaleimide (10 mg\/kg, s.c.), a blocker of sulfhydryl groups. This suggests that the gastroprotective mechanism of action of this compound involves NO, prostaglandins and sulfhydryl groups.<\/jats:p>","DOI":"10.3390\/molecules17088917","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T12:31:57Z","timestamp":1343305917000},"page":"8917-8927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryls"],"prefix":"10.3390","volume":"17","author":[{"given":"Carlos","family":"Vera-Arzave","sequence":"first","affiliation":[{"name":"Superior Medicine School, National Polytechnic Institute, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Mexico City, 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Cruz","family":"Antonio","sequence":"additional","affiliation":[{"name":"Zaragoza Faculty of Higher Studies, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ej\u00e9rcito de Oriente, Mexico City, 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Superior Medicine School, National Polytechnic Institute, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Mexico City, 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Cruz-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Superior Medicine School, National Polytechnic Institute, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Mexico City, 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Magdiel","family":"Vel\u00e1zquez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Technological University of the Jungle, Entronque Tonin\u00e1 Carretera Ocosingo-Altamirano, Ocosingo, State of Chiapas, 29950, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelfo","family":"Reyes-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Zaragoza Faculty of Higher Studies, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ej\u00e9rcito de Oriente, Mexico City, 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elena","family":"S\u00e1nchez-Mendoza","sequence":"additional","affiliation":[{"name":"Superior Medicine School, National Polytechnic Institute, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Mexico City, 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: Bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2165\/00002512-200724080-00005","article-title":"Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs","volume":"24","author":"Vonkeman","year":"2007","journal-title":"Drugs Aging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/phrs.1997.0168","article-title":"Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats","volume":"35","author":"Barocelli","year":"1997","journal-title":"Pharmacol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/molecules16010665","article-title":"Bioassay-guided isolation of an anti-ulcer compound, Tagitinin C, from Tithonia diversifolia: Role of nitric oxide, prostaglandins and sulfhydryls","volume":"16","author":"Arrieta","year":"2011","journal-title":"Molecules"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1095-8339.1988.tb01697.x","article-title":"Revision of generic limits in Hyptis Jacq. and its allies","volume":"98","author":"Harley","year":"1988","journal-title":"Bot. J. Linn. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/znc-2006-3-402","article-title":"Anti-inflammatory activity of two diterpenes of Hyptis suaveolens from El Salvador","volume":"61","author":"Grassi","year":"2006","journal-title":"Z. Naturforsch. C"},{"key":"ref_7","first-page":"49","article-title":"Antimicrobial studies on the extracts of Cocculus hirsutus Linn. and Hyptis suaveolens Poit","volume":"1","author":"Satish","year":"2010","journal-title":"Indian J. Nat. Prod. Resour."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jep.2005.08.018","article-title":"Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens","volume":"102","author":"Chukwujekwu","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jep.2011.03.002","article-title":"Gastroprotective and ulcer healing effects of essential oil from Hyptis spicigera Lam. (Lamiaceae)","volume":"135","author":"Takayama","year":"2011","journal-title":"J. Ethnopharmacol"},{"key":"ref_10","first-page":"82","article-title":"Phytochemical and pharmacological investigation of the protective effect of plant Hyptis suaveolens against duodenal ulceration","volume":"1","author":"Prabhat","year":"2009","journal-title":"J. Glob. Pharm. Technol."},{"key":"ref_11","first-page":"1027","article-title":"Chronic toxicity study of Hyptis suaveolens (L.) Poit in rats","volume":"27","author":"Attawish","year":"2005","journal-title":"Songklanakarin J. Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.fitote.2007.01.006","article-title":"Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice","volume":"78","author":"Santos","year":"2007","journal-title":"Fitoterapia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/SLA.0b013e3181b975b8","article-title":"Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006","volume":"251","author":"Wang","year":"2010","journal-title":"Ann. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jep.2004.08.017","article-title":"Preventive activity of pyrrolizidine alkaloids from Seneciobrasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats","volume":"95","author":"Toma","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1515\/znc-2005-7-801","article-title":"Gastroprotective effect and cytotoxicity of natural and semisynthetic labdane diterpenes from Araucaria araucana resin","volume":"60","author":"Astudillo","year":"2005","journal-title":"Z. Naturforsch. C"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1055\/s-2008-1074532","article-title":"New gastroprotective ferruginol derivatives with selective cytotoxicity against gastric cancer cells","volume":"74","author":"Espinoza","year":"2008","journal-title":"Planta Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1211\/jpp\/61.12.0015","article-title":"Gastroprotective effect and cytotoxicity of abietane diterpenes from the Chilean Lamiaceae Sphacele chamaedryoides (Balbis) Briq","volume":"61","author":"Areche","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1248\/bpb.25.452","article-title":"Natural trans-crotonin: The antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth","volume":"25","author":"Toma","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2009.02.008","article-title":"Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins","volume":"607","author":"Heeba","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/0929867053363478","article-title":"Gastric mucosal protection: From prostaglandins to gene-therapy","volume":"12","author":"Gyires","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1254\/jjp.78.285","article-title":"Role of glutathione in the antiulcer effect of hot water extract of black tea (Camellia sinensis)","volume":"78","author":"Maity","year":"1998","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.3390\/molecules15107153","article-title":"Mechanisms of the gastric antiulcerogenic activity of Anacardium humile St. Hil on ethanol-induced acute gastric mucosal injury in rats","volume":"15","author":"Almeida","year":"2010","journal-title":"Molecules"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/17\/8\/8917\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:51:28Z","timestamp":1760219488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/17\/8\/8917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,26]]},"references-count":22,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,8]]}},"alternative-id":["molecules17088917"],"URL":"https:\/\/doi.org\/10.3390\/molecules17088917","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,26]]}}}