{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:51:28Z","timestamp":1777938688149,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T00:00:00Z","timestamp":1345420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.<\/jats:p>","DOI":"10.3390\/molecules17089939","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T11:03:49Z","timestamp":1345460629000},"page":"9939-9946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii"],"prefix":"10.3390","volume":"17","author":[{"given":"Liang","family":"Xiong","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Jun","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Mei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China"},{"name":"Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Chengdu 610075, Sichuan, China"},{"name":"Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"ref_1","unstructured":"(1995). Dictionary of Traditional Chinese Medicine, Shanghai Science and Technology Publishing House."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hlca.201000152","article-title":"Two new C20-diterpenoid alkaloids from Aconitum carmichaelii","volume":"94","author":"Shen","year":"2011","journal-title":"Helv. Chim. Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/np300225t","article-title":"Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii","volume":"75","author":"Jiang","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/BF02978206","article-title":"Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaeli","volume":"28","author":"Shim","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"ref_5","first-page":"30","article-title":"Studies on the alkaloids and a new cardiac principle isolated from Jiangyou Fuzi (Aconitum carmichaelii Debx.)","volume":"9","author":"Han","year":"1997","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.chroma.2008.10.082","article-title":"Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots","volume":"1216","author":"Csupor","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.talanta.2008.10.022","article-title":"Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC\/ESIMS\/MSn","volume":"77","author":"Yue","year":"2009","journal-title":"Talanta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3987\/S(B)-1982-01-0047","article-title":"Fuziline, A new alkaloid from the Chinese drug \u201cFuzi\u201d (Aconitum carmichaeli Debx)","volume":"18","author":"Pelletier","year":"1982","journal-title":"Heterocycles"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3987\/COM-93-6638","article-title":"Norditerpenoid alkaloids from the aerial parts of Aconitum balfourii stapf","volume":"38","author":"Khetwal","year":"1994","journal-title":"Heterocycles"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1021\/np50026a006","article-title":"Structure of hokbusine A and B, diterpenic alkaloids of Aconitum carmichaeli roots from Japan","volume":"46","author":"Hikino","year":"1983","journal-title":"J. Nat. Prod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0367-326X(01)00344-6","article-title":"A new pyrrole alkaloid from seeds of Castanea sativa","volume":"73","author":"Hiermann","year":"2002","journal-title":"Fitoterapia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.phytochem.2005.08.011","article-title":"Alkaloids from Portulaca oleracea L","volume":"66","author":"Xiang","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/hlca.200800345","article-title":"Diterpenoid and norditerpenoid alkaloids from the roots of Aconitum yesoense var. macroyesoense","volume":"92","author":"Wada","year":"2009","journal-title":"Helv. Chim. Acta"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1055\/s-2005-873135","article-title":"Three new diterpene alkaloids from the roots of Aconitum nagarum var. lasiandrum","volume":"71","author":"Zhang","year":"2005","journal-title":"Planta Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3987\/COM-98-S40","article-title":"Alkaloids of some mongolian Ranunculaceae species: detailed 1H and 13C-NMR studies of denudatine and lepenine","volume":"49","author":"Batsuren","year":"1998","journal-title":"Heterocycles"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1021\/ol202121k","article-title":"Total synthesis and stereochemical revision of acortatarins A and B","volume":"13","author":"Sudhakar","year":"2011","journal-title":"Org. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/adsc.200900687","article-title":"Prolylprolinol catalyzed asymmetric michael addition of aliphatic aldehydes to nitroalkenes","volume":"352","author":"Lu","year":"2010","journal-title":"Adv. Synth. Catal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1021\/jo062382i","article-title":"An efficient synthesis of enantiomerically pure (R)-pipecolic acid, (S)-proline, And their N-alkylated derivatives","volume":"72","author":"Fadel","year":"2007","journal-title":"J. Org. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1016\/S0040-4020(01)86036-1","article-title":"Resolution and use in \u03b1-amino acid synthesis of imidazolidinone glycine derivatives","volume":"44","author":"Fitzi","year":"1988","journal-title":"Tetrahedron"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/17\/8\/9939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:51:52Z","timestamp":1760219512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/17\/8\/9939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,20]]},"references-count":19,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,8]]}},"alternative-id":["molecules17089939"],"URL":"https:\/\/doi.org\/10.3390\/molecules17089939","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,20]]}}}