{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:36:26Z","timestamp":1770039386454,"version":"3.49.0"},"reference-count":20,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro against one normal cell line (MRC-5 lung fibroblasts) and three human cancer cell lines (AGS human gastric adenocarcinoma; SK-MES-1 human lung cancer cells, and J82 human bladder carcinoma) in 72-h drug exposure assays using the MTT colorimetric method. Structure\u2013activity relationships within the series of angular quinones reveal that the insertion of pyrrol-2-yl and furan-2-yl groups at the 6-position is more significant for the increase of the potency and selectivity index of the pharmacophores.<\/jats:p>","DOI":"10.3390\/molecules171011616","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T02:39:08Z","timestamp":1349145548000},"page":"11616-11629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones"],"prefix":"10.3390","volume":"17","author":[{"given":"Jennyfer","family":"Iribarra","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"V\u00e1squez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santiago 8380492, Chile"},{"name":"Instituto de EtnoFarmacolog\u00eda (IDE), Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Theoduloz","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Benites","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"},{"name":"Instituto de EtnoFarmacolog\u00eda (IDE), Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"},{"name":"Instituto de EtnoFarmacolog\u00eda (IDE), Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime A.","family":"Valderrama","sequence":"additional","affiliation":[{"name":"Instituto de EtnoFarmacolog\u00eda (IDE), Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile"},{"name":"Facultad de Qu\u00edmica, Pontificia Universidad Cat\u00f3lica de Chile, Casilla 306, Santiago 6094411, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,28]]},"reference":[{"key":"ref_1","unstructured":"Morton, R.A. 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