{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:01:52Z","timestamp":1791406912430,"version":"4.3.3"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Solanum guaraniticum is a shrub belonging to the Solanaceae family popularly known in Brazil as jurubeba or false-jurubeba. The aim of this study was to evaluate the antioxidant activity of crude extract and chloroform, ethyl acetate and n-butanol fractions from its leaves, verifying the ability to remove reactive species and identify and quantify phenolic compounds. The ethyl acetate fraction showed the highest amount of total polyphenols (546.57 \u00b1 2.35 mg gallic acid equivalent\/g) and the lowest IC50 (9.11 \u00b1 0.75 \u00b5g\/mL) by the DPPH method. Furthermore, the chloroform fraction presented the highest content of flavonoids (75.73 \u00b1 0.34 mg rutin equivalents\/g), tannins (56.03 \u00b1 0.68 mg catechin equivalents\/g) and alkaloids (10.79 \u00b1 0.06 mg\/g). This fraction was effective in the scavenging of reactive species by 2\u2032,7\u2032-dichlorofluorescein diacetate assay, in addition to completely reducing protein carbonyl content and reducing lipid peroxidation at basal levels even at low concentrations. Chlorogenic, caffeic and rosmarinic acids were identified and quantified by HPLC\/DAD. These results show that S. guaraniticum is rich in phenolic compounds and has potential as an antioxidant.<\/jats:p>","DOI":"10.3390\/molecules171112560","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T11:00:57Z","timestamp":1351076457000},"page":"12560-12574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Antioxidant Activity and Phytochemical Composition of the Leaves of Solanum guaraniticum A. St.-Hil"],"prefix":"10.3390","volume":"17","author":[{"given":"Marina","family":"Zadra","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Piana","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiele Faccim de","family":"Brum","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Augusti","family":"Boligon","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Borba de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Mansur","family":"Machado","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Pampa-UNIPAMPA, Uruguaiana, RS 97500-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvio Terra","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Biochemical Toxicology, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix Alexandre Antunes","family":"Soares","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Biochemical Toxicology, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareth Linde","family":"Athayde","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS, 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.lfs.2003.09.047","article-title":"Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer","volume":"74","author":"Cai","year":"2004","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2005.04.028","article-title":"Antioxidant activity of some algerian medicinal plants extracts containing phenolic compounds","volume":"97","author":"Djeridane","year":"2006","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.foodchem.2009.02.021","article-title":"Phytochemical profiles and antioxidant activities of wine grapes","volume":"116","author":"Yang","year":"2009","journal-title":"Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.foodchem.2012.01.091","article-title":"Antioxidant activity and phenolic compounds of fractions from Portulaca oleracea L","volume":"133","author":"Erkan","year":"2012","journal-title":"Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. 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