{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:00:10Z","timestamp":1792047610464,"version":"4.4.0"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T00:00:00Z","timestamp":1351641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This review summarizes human infections caused by endoparasites, including protozoa, nematodes, trematodes, and cestodes, which affect more than 30% of the human population, and medicinal plants of potential use in their treatment. Because vaccinations do not work in most instances and the parasites have sometimes become resistant to the available synthetic therapeutics, it is important to search for alternative sources of anti-parasitic drugs. Plants produce a high diversity of secondary metabolites with interesting biological activities, such as cytotoxic, anti-parasitic and anti-microbial properties. These drugs often interfere with central targets in parasites, such as DNA (intercalation, alkylation), membrane integrity, microtubules and neuronal signal transduction. Plant extracts and isolated secondary metabolites which can inhibit protozoan parasites, such as Plasmodium, Trypanosoma, Leishmania, Trichomonas and intestinal worms are discussed. The identified plants and compounds offer a chance to develop new drugs against parasitic diseases. Most of them need to be tested in more detail, especially in animal models and if successful, in clinical trials.<\/jats:p>","DOI":"10.3390\/molecules171112771","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T11:59:41Z","timestamp":1351684781000},"page":"12771-12791","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":285,"title":["Medicinal Plants: A Source of Anti-Parasitic Secondary Metabolites"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7875-4510","authenticated-orcid":false,"given":"Michael","family":"Wink","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology, INF 364, Heidelberg University, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,10,31]]},"reference":[{"key":"ref_1","unstructured":"Van Wyk, B.-E., and Wink, M. (2004). Medicinal Plants of the World: An Illustrated Scientific Guide to Important Medicinal Plants and Their Uses, Timber Press."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np068054v","article-title":"Natural products as sources of new drugs over the last 25 years","volume":"70","author":"Newman","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wink, M. (2010). Functions and Biotechnology of Plant Secondary Metabolites, Wiley-Blackwell.","DOI":"10.1002\/9781444318876"},{"key":"ref_4","unstructured":"Peters, W., and Pasvol, G. (2007). Atlas of Tropical Medicine and Parasitology, Mosby-Elsevier. [6th]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.2174\/092986710790979953","article-title":"Trypanosomatid parasites causing neglected diseases","volume":"17","author":"Nussbaum","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_6","first-page":"171","article-title":"Production and application of phytochemicals from an agricultural perspective","volume":"Volume 34","author":"Breteler","year":"1993","journal-title":"Phytochemistry and Agriculture, Proceedings Phytochemical Society Of Europe"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1055\/s-0030-1270949","article-title":"Plant extracts, isolated phytochemicals, and plant-derived agents which are lethal to arthropod vectors of human tropical diseases\u2014A review","volume":"77","author":"Pohlit","year":"2011","journal-title":"Planta Med."},{"key":"ref_8","first-page":"1","article-title":"Molecular modes of action of cytotoxic alkaloids- From DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance","volume":"64","author":"Wink","year":"2007","journal-title":"Alkaloids"},{"key":"ref_9","unstructured":"Wink, M., and van Wyk, B.E. (2008). Mind-Altering and Poisonous Plants of the World, Timber Press."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wink, M. (2010). Functions and Biotechnology of Plant Secondary Metabolites, Wiley-Blackwell.","DOI":"10.1002\/9781444318876"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0031-9422(96)00545-6","article-title":"Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores","volume":"44","author":"Schmeller","year":"1997","journal-title":"Phytochemistry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.2174\/092986707781368441","article-title":"Molecular target-guided tumor therapy with natural products derived from Traditional Chinese Medicine","volume":"14","author":"Efferth","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.3390\/molecules13102462","article-title":"Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei)","volume":"13","author":"Rosenkranz","year":"2008","journal-title":"Molecules"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/med.20242","article-title":"Drugs that target dynamic microtubules: A new molecular perspective","volume":"31","author":"Stanton","year":"2011","journal-title":"Med. Res. Rev."},{"key":"ref_15","first-page":"1","article-title":"Characteristics of apoptosis induction by the alkaloid emetine in human tumor cell lines","volume":"73","author":"Wink","year":"2007","journal-title":"Planta Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2174\/138920008786927794","article-title":"Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine","volume":"9","author":"Wink","year":"2008","journal-title":"Curr. Drug. Metab."},{"key":"ref_17","first-page":"3","article-title":"Interference of alkaloids with neuroreceptors and ion channels","volume":"21","author":"Wink","year":"2000","journal-title":"Stud. Nat. Prod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1055\/s-0030-1250548","article-title":"Improved traditional phytomedicines in current use for the clinical treatment of malaria","volume":"77","author":"Willcox","year":"2011","journal-title":"Planta Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2012.00130","article-title":"Secondary metabolites inhibiting ABC transporters and reversing resistance of cancer cells and fungi to cytotoxic and antimicrobial agents","volume":"3","author":"Wink","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.phymed.2011.06.008","article-title":"Cytotoxic activity towards cancer cells of secondary constituents derived from Artemisia annua L. in comparison to its designated active constituent artemisinin","volume":"18","author":"Efferth","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_21","first-page":"385","article-title":"Artemisinin\u2014An innovative cornerstone for anti-malarial therapy","volume":"66","author":"Kuhn","year":"2008","journal-title":"Prog. Drug Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1055\/s-0030-1250405","article-title":"Natural products published in 2009 from plants traditionally used to treat malaria","volume":"77","author":"Bero","year":"2011","journal-title":"Planta Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1211\/jpp.61.11.0001","article-title":"Antimalarial compounds isolated from plants used in traditional medicine","volume":"61","author":"Bero","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_24","first-page":"1181","article-title":"Non-nitrogenous plant-derived constituents with antiplasmodial activity","volume":"1","author":"Bilia","year":"2006","journal-title":"Nat. Prod. Comm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/713610851","article-title":"Review: Natural antimalarial agents (1995-2001)","volume":"22","author":"Caniato","year":"2003","journal-title":"Crit. Rev. Plant Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2174\/1568026023393011","article-title":"Natural products as trypanocidal, antileishmanial and antimalarial drugs","volume":"2","author":"Fournet","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1055\/s-0030-1250549","article-title":"Curcuma as a parasiticidal agent: A review","volume":"77","author":"Haddad","year":"2011","journal-title":"Planta Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e8682","DOI":"10.1371\/journal.pone.0008682","article-title":"Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility","volume":"5","author":"Hellmann","year":"2010","journal-title":"PLoS One"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.bmc.2009.02.050","article-title":"Antimalarials from nature","volume":"17","author":"Kaur","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/molecules16032146","article-title":"Antiplasmodial natural products","volume":"16","author":"Nogueira","year":"2011","journal-title":"Molecules"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0035-9203(94)90464-2","article-title":"Natural products as drugs","volume":"88","author":"Phillipson","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_32","first-page":"1314","article-title":"Antimalarial agents from plant sources","volume":"85","author":"Saxena","year":"2003","journal-title":"Curr. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1039\/b008980j","article-title":"Antimalarial activity of plant metabolites","volume":"19","author":"Schwikkard","year":"2003","journal-title":"Nat. Prod. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11101-005-3261-7","article-title":"Plant derived antimalarial agents: new leads and challenges","volume":"4","author":"Wright","year":"2005","journal-title":"Phytochem. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Eid, S.Y., El-Readi, M.Z., and Wink, M. (2012). Digitonin synergistically enhances the cytotoxicity of plant secondary metabolites in cancer cells. Phytomedicine.","DOI":"10.1016\/j.phymed.2012.09.002"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Eid, S.Y., El-Readi, M.Z., and Wink, M. (2012). Synergism of three-drug combinations of sanguinarine and other plant secondary metabolites with digitonin and doxorubicin in multi-drug resistant cancer cells. Phytomedicine, in press.","DOI":"10.1016\/j.phymed.2012.08.010"},{"key":"ref_37","first-page":"411","article-title":"Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products","volume":"22","author":"Gehrig","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0030-1250411","article-title":"Sleeping sickness pathogen (Trypanosoma brucei) and natural products: Therapeutic targets and screening systems","volume":"77","author":"Hannaert","year":"2011","journal-title":"Planta Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1039\/b311021b","article-title":"Natural products active against African trypanosomes: a step towards new drugs","volume":"21","author":"Hoet","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2003.11.008","article-title":"In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants","volume":"91","author":"Hoet","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.2174\/092986706778201611","article-title":"Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis","volume":"13","author":"Salem","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1055\/s-2001-17351","article-title":"In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.","volume":"67","author":"Merschjohann","year":"2001","journal-title":"Planta Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ptr.3066","article-title":"Antitrypanosomal and cytotoxic activities of some Tanzanian medicinal plants","volume":"24","author":"Nibret","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1211\/jpp.61.06.0014","article-title":"Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid producing plants of Ethiopia","volume":"61","author":"Nibret","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.phymed.2010.02.009","article-title":"Chemical composition of essential oils from Hagenia abyssinica, Leonotis ocymifolia and Moringa stenopetala and structure activity relationships of isolated terpenoids in trypanosomes (Trypanosoma b. brucei) and human leucaemia cells (HL-60)","volume":"17","author":"Nibret","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.phymed.2009.07.016","article-title":"In vitro antitrypanosomal and cytotoxic activities of four Artemisia species (Asteraceae) from Ethiopia","volume":"17","author":"Nibret","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1055\/s-0031-1279984","article-title":"Carlina oxide- a natural polyacetylene from Carlina acaulis (Asteraceae) with potent antitrypanosomal and antimicrobial properties","volume":"77","author":"Herrmann","year":"2011","journal-title":"Planta Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Herrmann, F., Tahrani, A., and Wink, M. (2012). Antitrypanosomal properties of Panax ginseng CA Meyer\u2014New possibilities for a remarkable traditional drug!. Phytother. Res.","DOI":"10.1002\/ptr.4692"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1073\/pnas.92.9.3726","article-title":"Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmani","volume":"92","author":"Bodley","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1645\/0022-3395(2002)088[0600:CLBTOT]2.0.CO;2","article-title":"Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro","volume":"88","author":"Ochola","year":"2002","journal-title":"J. Parasitol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-0030-1250663","article-title":"Current approaches to discover marine antileishmanial natural products","volume":"77","author":"Tempone","year":"2011","journal-title":"Planta Med."},{"key":"ref_52","first-page":"277","article-title":"Leishmaniasis: Drug resistance and natural products (review)","volume":"22","author":"Polonio","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.pt.2009.06.006","article-title":"Reporter genes facilitating discovery of drugs targeting protozoan parasites","volume":"25","author":"Dube","year":"2009","journal-title":"Trends Parasitol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1874847300902010021","article-title":"Development of drug resistance in Trichomonas vaginalis and its overcoming with natural products","volume":"2","author":"Gehrig","year":"2009","journal-title":"Open Bioact. Comp. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2174\/092986711794480096","article-title":"Chemistry and pharmacology of neglected helminthic diseases","volume":"18","author":"Helfer","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1055\/s-0030-1250452","article-title":"Plant products in the treatment and control of filariasis and other helminth infections and assay systems for antifilarial\/anthelminthic activity","volume":"77","author":"Murthy","year":"2011","journal-title":"Planta Med."},{"key":"ref_57","first-page":"1","article-title":"New antifilaricicidal leads from plant?","volume":"41","author":"Comley","year":"1990","journal-title":"Trop. Med. Parasitol."},{"key":"ref_58","first-page":"108","article-title":"Streblus asper\u2014An ancient Indian drug for the cure of filariasis","volume":"15","author":"Singh","year":"1987","journal-title":"Acta Bot. Indica"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ddr.430260106","article-title":"Macrofilaricidal activity of the stem bark of Streblus asper and its major active constituents","volume":"26","author":"Chatterjee","year":"1992","journal-title":"Drug Dev. Res."},{"key":"ref_60","first-page":"19","article-title":"Screening of West African plants for anthelmintic activity","volume":"17","author":"Ibrahim","year":"1984","journal-title":"ILCA Bull."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-3156.1997.d01-242.x","article-title":"Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae) and phorbolesters from Jatropha curcas (Euphorbiaceae) with molluscicidal activity against schistosomias vector snails Oncomelania, Biomphalaria and Bulinus","volume":"2","author":"Liu","year":"1997","journal-title":"Trop. Med. Intl. Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0277-9536(85)90144-3","article-title":"Studies on the traditional herb anthelmintic Chenopodium ambrosioides L. Ethnopharmacological evaluation and clinical field trials","volume":"21","author":"Kliks","year":"1985","journal-title":"Soc. Sci. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.trstmh.2003.09.001","article-title":"Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria","volume":"98","author":"Mueller","year":"2004","journal-title":"Trans. R. Soc. Trop. Med. Hyg."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/17\/11\/12771\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:53:13Z","timestamp":1760219593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/17\/11\/12771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,31]]},"references-count":63,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11]]}},"alternative-id":["molecules171112771"],"URL":"https:\/\/doi.org\/10.3390\/molecules171112771","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,31]]}}}