{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T12:40:07Z","timestamp":1775392807289,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We report herein the synthesis and characterization of 9-(2-diallylaminoethyl) adenine. We evaluated two different synthetic routes starting with adenine where the optimal route was achieved through coupling of 9-(2-chloroethyl)adenine with diallylamine. The cyclopolymerization and cyclo-copolymerization of 9-(2-diallylaminoethyl)adenine hydrochloride salt resulted in low molecular weight oligomers in low yields. In contrast, 9-(2-diallylaminoethyl)adenine failed to cyclopolymerize, however, it formed a copolymer with SO2 in relatively good yields. The molecular weights of the cyclopolymers were around 1,700\u20136,000 g\/mol, as estimated by SEC. The cyclo-copolymer was stable up to 226 \u00b0C. To the best of our knowledge, this is the first example of a free-radical cyclo-copolymerization of a neutral alkyldiallylamine derivative with SO2. These polymers represent a novel class of carbocyclic polynucleotides.<\/jats:p>","DOI":"10.3390\/molecules171113290","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T11:04:29Z","timestamp":1352372669000},"page":"13290-13306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis, Cyclopolymerization and Cyclo-Copolymerization of 9-(2-Diallylaminoethyl)adenine and Its Hydrochloride Salt"],"prefix":"10.3390","volume":"17","author":[{"given":"Kamal","family":"Bouhadir","sequence":"first","affiliation":[{"name":"Department of Chemistry, American University of Beirut, Box 11-0236, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Abramian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, American University of Beirut, Box 11-0236, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Ezzeddine","sequence":"additional","affiliation":[{"name":"Department of Chemistry, American University of Beirut, Box 11-0236, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyn","family":"Usher","sequence":"additional","affiliation":[{"name":"Department of Chemistry, West Chester University, West Chester, PA 19383, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Vladimirov","sequence":"additional","affiliation":[{"name":"Ashland Research Center, 500 Hercules Road, Wilmington, DE 19808, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/3-540-46414-X_1","article-title":"Polynucleotide analogues","volume":"153","author":"Han","year":"2000","journal-title":"Adv. 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