{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:00:50Z","timestamp":1760853650729,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure.<\/jats:p>","DOI":"10.3390\/molecules171214146","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T11:03:39Z","timestamp":1354100619000},"page":"14146-14158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-8998","authenticated-orcid":false,"given":"Chengyuan","family":"Liang","sequence":"first","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizheng","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/12020188","article-title":"Synthesis and Photochemistry of 1-Iodocyclohexene: Influence of Ultrasound on Ionic vs. Radical Behaviour","volume":"12","author":"Blaskovicova","year":"2007","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/12082080","article-title":"Ultrasound Assisted Synthesis of 5,9-Dimethylpentadecane and 5,9-Dimethylhexadecane-The Sex Pheromones of Leucoptera coffeella","volume":"12","author":"Doan","year":"2007","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.3390\/molecules14041423","article-title":"Ultrasound Promoted Synthesis of Bis (substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas","volume":"14","author":"Xiao","year":"2009","journal-title":"Molecules"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.3390\/molecules15042087","article-title":"Ultrasound-Assisted Synthesis of Novel 4-(2-Phenyl-1,2,3-Triazol-4-yl)-3,4-Dihydropyrimidin-2(1H)-(Thio)ones Catalyzed by Sm(ClO4)3","volume":"15","author":"Liu","year":"2010","journal-title":"Molecules"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.3390\/molecules17078674","article-title":"Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives","volume":"17","author":"Wang","year":"2012","journal-title":"Molecules"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10708","DOI":"10.3390\/molecules170910708","article-title":"An Improved Synthesis of 1,2-Diarylethanols under Conventional Heating and Ultrasound Irradiation","volume":"17","author":"Gao","year":"2012","journal-title":"Molecules"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.3390\/molecules17089335","article-title":"A Convenient Ultrasound-Promoted Synthesis of Some New Thiazole Derivatives Bearing a Coumarin Nucleus and Their Cytotoxic Activity","volume":"17","author":"Gomha","year":"2012","journal-title":"Molecules"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJM196703022760904","article-title":"Potentiation of anticoagulant effect of warfarin by phenylbutazone","volume":"276","author":"Aggeler","year":"1967","journal-title":"N. 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