{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:37:27Z","timestamp":1785332247489,"version":"3.55.0"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennial climbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic and antilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may represent an important pathogenic mechanism in obesity-associated metabolic syndrome. The present study evaluated free radical scavenging capacity of different concentrations of aqueous, methanolic and dichloromethane leaf extracts of Momordica foetida Schumach. et Thonn. and the ability of these extracts to inhibit in vitro plasma lipid peroxidation; in addition, healthy human adipose mesenchymal stem cell cultures were used in order to test the hypothesis that these extracts may affect adipocyte differentiation. Results obtained in this study suggested that aqueous extract might be useful in preventing metabolic syndrome.<\/jats:p>","DOI":"10.3390\/molecules18033241","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T12:14:49Z","timestamp":1363176889000},"page":"3241-3249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Antioxidant Activity of Extracts of Momordica Foetida Schumach. et Thonn."],"prefix":"10.3390","volume":"18","author":[{"given":"Rosaria","family":"Acquaviva","sequence":"first","affiliation":[{"name":"Department of Drug Science\u2014Biochemistry Section, University of Catania, Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Department of Drug Science\u2014Biochemistry Section, University of Catania, Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Vanella","sequence":"additional","affiliation":[{"name":"Department of Drug Science\u2014Biochemistry Section, University of Catania, Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Department of Drug Science\u2014Biochemistry Section, University of Catania, Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Sorrenti","sequence":"additional","affiliation":[{"name":"Department of Drug Science\u2014Biochemistry Section, University of Catania, Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-0662","authenticated-orcid":false,"given":"Ignazio","family":"Barbagallo","sequence":"additional","affiliation":[{"name":"Department of Drug Science\u2014Biochemistry Section, University of Catania, Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-9047","authenticated-orcid":false,"given":"Carlo","family":"Genovese","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Sciences, Section of Microbiology, University of Catania,  Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Mastrojeni","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Sciences, Section of Microbiology, University of Catania,  Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Ragusa","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University \"Magna Graecia\" of Catanzaro, Catanzaro 88100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Iauk","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Sciences, Section of Microbiology, University of Catania,  Catania 95125, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Determination of Antioxidant Potential of Momordica Foetida Leaf Extract on Tissue Homogenate","volume":"2012","author":"Oloyede","year":"2012","journal-title":"Sci. Med. Clin. Trials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-8741(92)90014-I","article-title":"Screening of Rwandese Medicinal-Plants for Anti-Trichomonas Activity","volume":"36","author":"Hakizamungu","year":"1992","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0102-695X2007000100002","article-title":"Plants traditionally used against malaria: Phytochemical and pharmacological investigation of Momordica foetida","volume":"17","author":"Froelich","year":"2007","journal-title":"Braz. J. Pharm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1271\/bbb.60570","article-title":"Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction","volume":"71","author":"Oishi","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349710","DOI":"10.1155\/2012\/349710","article-title":"Exercise in the metabolic syndrome","volume":"2012","author":"Golbidi","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0899-9007(00)00424-X","article-title":"A concise review on the therapeutics of obesity","volume":"16","author":"Bray","year":"2000","journal-title":"Nutrition"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jnutbio.2007.06.011","article-title":"Oxidative stress-induced risk factors associated with the metabolic syndrome: A unifying hypothesis","volume":"19","author":"Grattagliano","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2478\/s11658-010-0042-0","article-title":"Differential redox potential profiles during adipogenesis and osteogenesis","volume":"16","author":"Imhoff","year":"2011","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1074\/jbc.M808742200","article-title":"Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_10","unstructured":"Chaudhari, P., Ye, Z., and Jang, Y.Y. (2012). Roles of Reactive Oxygen Species in the Fate of Stem Cells. Antioxid. Redox Signal."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.lfs.2011.06.007","article-title":"Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells","volume":"89","author":"Kanda","year":"2011","journal-title":"Life Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1002\/jcp.22542","article-title":"Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells","volume":"226","author":"Vigilanza","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00774-009-0134-y","article-title":"Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation","volume":"28","author":"Barbagallo","year":"2010","journal-title":"J. Bone Miner. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bone.2009.10.012","article-title":"HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage","volume":"46","author":"Vanella","year":"2010","journal-title":"Bone"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1089\/scd.2012.0306","article-title":"Differentiation of Human Adipose-Derived Stem Cells into Fat Involves Reactive Oxygen Species and Forkhead Box O1 Mediated Upregulation of Antioxidant Enzymes","volume":"22","author":"Higuchi","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1634\/stemcells.2007-1122","article-title":"In search of the in vivo identity of mesenchymal stem cells","volume":"26","author":"Caplan","year":"2008","journal-title":"Stem Cells"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.stem.2008.08.008","article-title":"All MSCs are pericytes?","volume":"3","author":"Caplan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0041-008X(90)90278-3","article-title":"Organometal-induced increases in oxygen reactive species: The potential of 2',7'-dichlorofluorescin diacetate as an index of neurotoxic damage","volume":"104","author":"LeBel","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.foodchem.2009.11.063","article-title":"Microwave-assisted extraction of phenolic antioxidant compounds from peanut skins","volume":"120","author":"Ballard","year":"2010","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0308-8146(98)00102-2","article-title":"The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals","volume":"64","author":"Jia","year":"1999","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/14786419.2012.695364","article-title":"Antimicrobial and antioxidant properties of Betula aetnensis Rafin. (Betulaceae) leaves extract","volume":"27","author":"Acquaviva","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"Ferrous Ion Oxidation in Presence of Ferric Ion Indicator Xylenol Orange for Measurement of Hydroperoxides","volume":"233","author":"Wolff","year":"1994","journal-title":"Method Enzymol."},{"key":"ref_26","first-page":"31","article-title":"Antiproliferative effect of oleuropein in prostate cell lines","volume":"41","author":"Acquaviva","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/18\/3\/3241\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:45:30Z","timestamp":1760219130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/18\/3\/3241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,13]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3]]}},"alternative-id":["molecules18033241"],"URL":"https:\/\/doi.org\/10.3390\/molecules18033241","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,13]]}}}